Efficacy and safety of short- and long-term, regular and on-demand regimens of phosphodiesterase type 5 inhibitors in treating erectile dysfunction after nerve-sparing radical prostatectomy: a systematic review and meta-analysis
Efficacy and safety of short- and long-term, regular and on-demand regimens of phosphodiesterase type 5 inhibitors in treating erectile dysfunction after nerve-sparing radical prostatectomy: a systematic review and meta-analysis
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DOI：
10.2147/cia.s122273
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发表时间：
2017-01-01
影响因子：
3.6
通讯作者：
Zhang, Yong
中科院分区：
文献类型：
--
作者：
Tian, Daxue;Wang, Xiao-yan;Zhang, Yong
背景资料：我们进行了一项荟萃分析，以评估短期（6个月），定期（OaD）和按需（PRN）方案的磷酸二酯酶5型抑制剂（PDE 5-Is）治疗勃起功能障碍（艾德）的有效性和安全性保留神经的根治性直肠癌切除术（NSRP）后。方法：我们在2016年8月进行了文献检索。来源包括PubMed、EMBASE和MEDLINE数据库。结果：共纳入8篇文献，涉及13项随机对照试验，研究结果表明，PDE 5-Is在短期和长期内均能明显改善IIEF-EF，与安慰剂相比，PDE 5-Is能明显改善IIEF-EF（平均差异[MD]：2.26，95%置信区间[CI]：1.45-3.08，P < 0.00001，MD：4.5，95% CI：长期应用PDE 5-Is（>6个月）较短期应用PDE 5-Is（3.6-5.4，P < 0.00001）可明显改善IIEF-EF（
Background: We performed a meta-analysis to evaluate the efficacy and safety of short-term (6 months), regular (OaD) and on-demand (PRN) regimens of phosphodiesterase type 5 inhibitors (PDE5-Is) in treating erectile dysfunction (ED) after nerve-sparing radical prostatectomy (NSRP).Methods: We conducted a literature search in August 2016. Sources included PubMed, EMBASE, and MEDLINE databases. The main outcome was International Index of Erectile Function-Erectile Function (IIEF-EF) domain score, and the secondary outcome was treatment-emergent adverse events (TEAEs).Results: Eight articles involving 13 randomized controlled trials (RCTs) were used in this analysis: they suggested that PDE5-Is can improve the IIEF-EF distinctly in comparison with placebo in short and long term (mean difference [MD]: 2.26, 95% confidence interval [CI]: 1.45-3.08, P < 0.00001, and MD: 4.5, 95% CI: 3.6-5.4, P < 0.00001), and long-term use of PDE5-Is (>6 months) can improve the IIEF-EF distinctly in comparison with short-term use of PDE5-Is (