Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection
Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection
复制标题
DOI：
10.1038/ni1136
复制
发表时间：
2004-12-01
影响因子：
30.5
通讯作者：
Oldstone, MBA
中科院分区：
文献类型：
--
作者：
Zuniga, EI;McGavern, DB;Oldstone, MBA
树突状细胞（DC）的两个亚群，浆细胞样（p）和髓样（m）DC，已经在人类和小鼠中描述。已知这些亚群在免疫应答期间具有不同的作用，但它们的发育过程尚不清楚。在这里，我们报告说，病毒感染诱导骨髓pDCs分化成mDCs，从而经历了深刻的表型和功能的变化，包括收购增强的抗原呈递能力和识别不同的微生物结构的能力，通过Toll样受体4。pDC向mDC的转化也通过注射双链RNA诱导，并且需要I型干扰素。我们的研究结果建立了这两个DC亚群之间的免疫产物发育关系，并突出了骨髓pDC的意外可塑性。
Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of enhanced antigen-presenting capacity and the ability to recognize different microbial structures through Toll-like receptor 4. The conversion of pDCs into mDCs is also induced by the injection of double-stranded RNA and requires type I interferons. Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs.