Age differences in corneal hydration control.
Age differences in corneal hydration control.
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发表时间：
1989-03
影响因子：
4.4
通讯作者：
K. Polse;Richard J. Brand;Robert B. Mandell;D. Vastine;D. Demartini;R. Flom
中科院分区：
文献类型：
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作者：
K. Polse;Richard J. Brand;Robert B. Mandell;D. Vastine;D. Demartini;R. Flom
对8名青年和8名老年正常人(平均年龄分别为24.4±4.3岁和71.9±7.3岁)的角膜厚度动态变化进行了测量，为定量评估角膜水化控制提供数据，从而为研究角膜功能这一重要方面的年龄差异提供信息。对于每个受试者，通过(A)监测低氧应激后的角膜恢复，并通过(B1)测量睡眠后的恢复或(B2)通过测量下午晚些时候的角膜厚度来获得厚度测量数据。A和B1或A和B2的联合数据通过指数模型进行分析，以提供以下信息：(1)诱导角膜水化后的每小时恢复率(PRPH)；(2)睁眼稳态(OESS)角膜厚度；(3)低氧应激试验前的残余角膜肿胀；(4)低氧应激导致的角膜水肿量；(5)达到OESS厚度水平的95%恢复时间(T95%)。结果表明，在两个年龄段之间，角膜水化的某些特征有很大差异，而其他方面是相似的。例如，年轻受试者的平均PRPH值(58.9+/-7.8%和34.2+/-6.4%/小时)显著高于老年受试者(P=0.0002)，而平均95%恢复到OESS厚度的时间(207+/-42min和452+/-117min)显著低于老年组(P=0.0002)。
Dynamic changes in corneal thickness were measured in eight young and eight older normal subjects (mean ages 24.4 +/- 4.3 years and 71.9 +/- 7.3 years, respectively) to provide data for quantitative assessment of corneal hydration control and thereby provide information for studying age differences in this important aspect of corneal function. For each subject, pachometry data were obtained by (A) monitoring corneal recovery following hypoxic stress, and by either (B1) measuring recovery after sleep or (B2) by measuring corneal thickness in the late afternoon. The combined data from A and B1 or A and B2 were analyzed through an exponential model to provide information on the: (1) percent recovery per hour (PRPH) following induced corneal hydration; (2) open-eye steady-state (OESS) corneal thickness; (3) residual corneal swelling just before the hypoxic stress test; (4) amount of corneal edema induced by hypoxic stress; and (5) time to reach 95% recovery back to the OESS thickness level (T95%). The results show that between the two age groups, there are substantial differences in some characteristics of corneal hydration while other aspects are similar. For example, the mean PRPH values (58.9 +/- 7.8% and 34.2 +/- 6.4%/hr) were significantly higher in the younger subjects (P = 0.0002) and the mean time for 95% recovery to OESS thickness (207 +/- 42 min and 452 +/- 117 min) was significantly lower in the younger vs. the older group (P = 0.0002).(ABSTRACT TRUNCATED AT 250 WORDS)