Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid.
Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid.
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DOI：
10.4103/0973-7847.194044
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Parasuraman S
中科院分区：
文献类型：
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作者：
Anand David AV;Arulmoli R;Parasuraman S
抗氧化剂是可以保护细胞免受自由基等不稳定分子损害的物质。黄酮类化合物是广泛存在于水果和蔬菜中的酚类物质。以前的研究表明，摄入黄酮类化合物可以降低心血管疾病，代谢紊乱和某些类型癌症的风险。这些作用是由于黄酮类化合物在减少氧化应激、抑制低密度脂蛋白氧化和血小板聚集以及在血管中充当血管扩张剂方面的生理活性。自由基不断产生，导致对组织的广泛损伤，导致各种疾病状况，如癌症、阿尔茨海默氏症、肾病、心脏异常等，具有抗氧化特性的药用植物在显示有益效果方面发挥着重要作用，并被用作减轻与氧化应激相关的疾病的替代药物来源。黄酮类化合物已经存在超过10亿年，具有广泛的生物活性，可能能够影响疾病中失调的过程。槲皮素是一种植物色素，是一种有效的抗氧化剂类黄酮，更具体地说是一种黄酮醇，主要存在于洋葱，葡萄，浆果，樱桃，花椰菜和柑橘类水果中。它是一种多用途的抗氧化剂，已知具有保护能力，防止各种药物毒性引起的组织损伤。
Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables. The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, metabolic disorders, and certain types of cancer. These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins oxidation and platelet aggregation, and acting as vasodilators in blood vessels. Free radicals are constantly generated resulting in extensive damage to tissues leading to various disease conditions such as cancer, Alzheimer's, renal diseases, cardiac abnormalities, etc., Medicinal plants with antioxidant properties play a vital functions in exhibiting beneficial effects and employed as an alternative source of medicine to mitigate the disease associated with oxidative stress. Flavonoids have existed over one billion years and possess wide spectrum of biological activities that might be able to influence processes which are dysregulated in a disease. Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits. It is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.