Chromone and flavonoid alkaloids: occurrence and bioactivity.

Chromone and flavonoid alkaloids: occurrence and bioactivity.
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Chromone和类黄酮生物碱:发生和生物活性。

DOI:
10.3390/molecules17010191
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发表时间:
2011-12-27
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
Marles RJ
Marles RJ
中科院分区:
其他
文献类型:
--
作者:
Khadem S;Marles RJ

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色酮和类黄酮生物碱代表了一组不寻常的结构多样的次级代谢产物,来自广泛分布于植物和动物界的多种生物合成途径的融合。其中许多是通过对传统药物进行生物测定指导的化学研究发现的,表明了潜在的治疗意义。它们独特的结构和多样的药理活性可能为发现具有新作用机制的药物提供重要的新线索。潜在的治疗适应症多种多样,如癌症和病毒感染、炎症和免疫调节、神经和精神疾病以及糖尿病。
The chromone and flavonoid alkaloids represent an unusual group of structurally diverse secondary metabolites, derived from the convergence of multiple biosynthetic pathways that are widely distributed through the plant and animal kingdoms. Many of them have been discovered through bioassay-guided chemical investigations of traditional medicines, suggesting potential therapeutic significance. Their unique structures and varied pharmacological activities may provide important new leads for the discovery of drugs with novel mechanisms of action. Potential therapeutic indications are as diverse as cancer and viral infections, inflammation and immunomodulation, neurological and psychiatric conditions, and diabetes.
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