Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia
Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia
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DOI：
10.1186/1472-6890-11-10
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发表时间：
2011-01-01
影响因子：
--
通讯作者：
Boyajyan, Anna
中科院分区：
文献类型：
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作者：
Arakelyan, Arsen;Zakharyan, Roksana;Boyajyan, Anna
背景：虽然补体系统的改变有助于精神分裂症，但补体受体和调节因子的研究很少。我们研究了精神分裂症患者和对照组中补体受体1 （CR1）在血细胞中的表达，含CR1、C1q补体蛋白和C3补体蛋白片段（C1q-CIC, C3d-CIC）配体的循环免疫复合物（CIC）水平，以及CR1 C5507G功能多态性。结果：我们发现，与对照组相比，患者血细胞中C1q-CIC水平和CR1表达增加，CR1阳性红细胞数量增加，CR1阳性淋巴细胞和单核细胞数量减少。各组间C3d-CIC水平无差异。两组CC基因型红细胞中CR1的表达均高于CG+GG，而其他细胞群中CR1的表达无差异。我们的研究结果表明，精神分裂症与CR1表达和C1q-CIC水平升高有关。结论：我们的研究首次表明精神分裂症与CR1表达和C1q-CIC水平升高有关。需要在其他种族群体中进行进一步的研究来重复这些发现。
Background: Whereas the complement system alterations contribute to schizophrenia, complement receptors and regulators are little studied. We investigated complement receptor type 1 (CR1) expression on blood cells, the levels of circulating immune complexes (CIC) containing ligands of CR1, C1q complement protein and fragments of C3 complement protein (C1q-CIC, C3d-CIC), and CR1 C5507G functional polymorphism in schizophrenia patients and controls.Results: We found an increased C1q-CIC level and CR1 expression on blood cells, elevated number of CR1 positive erythrocytes and reduced number of CR1 positive lymphocytes and monocytes in patients compared to controls. No difference in the levels of C3d-CIC between groups was observed. Higher CR1 expression on erythrocytes in CC genotype versus CG+GG for both groups was detected, whereas no difference was observed for other cell populations. Our results indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level.Conclusions: Our study for the first time indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level. Further studies in other ethnic groups are needed to replicate these findings.