Immunity to seasonal and pandemic influenza A viruses.

Immunity to seasonal and pandemic influenza A viruses.
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DOI:
10.1016/j.micinf.2011.01.007
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发表时间:
2011-05
影响因子:
5.8
通讯作者:
Kedzierska K
Kedzierska K
中科院分区:
医学3区
文献类型:
--
作者:
Valkenburg SA;Rutigliano JA;Ellebedy AH;Doherty PC;Thomas PG;Kedzierska K

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一种新的流感毒株进入人体循环导致全球迅速传播。本文综述了对流感病毒的先天性和适应性免疫,重点是T细胞反应,提供不同亚型和毒株之间的交叉保护。我们讨论了T细胞免疫原性肽内的抗原变异和我们对2009年甲型H1N1流感大流行毒株预先存在的免疫力的理解。
The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain.
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