Hemodynamics and Vascular Hypertrophy in African Americans and Caucasians With High Blood Pressure.
Hemodynamics and Vascular Hypertrophy in African Americans and Caucasians With High Blood Pressure.
复制标题
患有高血压的非裔美国人和白种人的血流动力学和血管肥大。
DOI：
10.1093/ajh/hpw080
复制
发表时间：
2016
影响因子：
3.2
通讯作者：
Hinderliter,AlanL
中科院分区：
文献类型：
--
作者：
Hill,LaBarronK;Sherwood,Andrew;Blumenthal,JamesA;Hinderliter,AlanL
背景与白人相比，非裔美国人的高血压以更大的全身血管阻力（SVR）为特征，但其机制尚不清楚。本研究旨在确定外周血管肥大是否是一个潜在的机制，有助于提高SVR在非洲裔美国人与高血压（BP）。METHODS在birthday样本的80名男性和女性之间的年龄为25和45岁，与临床血压在130/85-160/99毫米汞柱的范围内，我们评估了心输出量和SVR，除了BP。最小前臂血管阻力（MFVR）是血管肥大的标志，非裔美国人的MFTSSVR高于白人（P< 0.001）。回归模型显示年龄、体重指数、24小时舒张压和种族是SVR的显著预测因素。在解释研究样本中的SVR时，种族和MFVR之间也存在显著的相互作用。特别是，有一个显着的正相关MFVR和SVR之间的非裔美国人（P= 0.002），而该协会是反向的，没有统计学意义的高加索人（P= 0.601）。CONCLUSIONHypertrophy的全身微血管系统可能有助于SVR升高，这是高血压的早期阶段，在非洲裔美国人相比，高加索人。
BACKGROUNDHypertension in African Americans is characterized by greater systemic vascular resistance (SVR) compared with Caucasian Americans, but the responsible mechanisms are not known. The present study sought to determine if peripheral vascular hypertrophy is a potential mechanism contributing to elevated SVR in African Americans with high blood pressure (BP).METHODSIn a biracial sample of 80 men and women between the ages of 25 and 45 years, with clinic BP in the range 130/85–160/99mm Hg, we assessed cardiac output and SVR, in addition to BP. Minimum forearm vascular resistance (MFVR), a marker of vascular hypertrophy, also was assessed.RESULTSSVR was elevated in African Americans compared with Caucasians (P< 0.001). Regression models indicated that age, body mass index, 24-hour diastolic BP, and ethnicity were significant predictors of SVR. There was also a significant interaction between ethnicity and MFVR in explaining SVR in the study sample. In particular, there was a significant positive association between MFVR and SVR among African Americans (P= 0.002), whereas the association was inverse and not statistically significant among Caucasians (P= 0.601).CONCLUSIONHypertrophy of the systemic microvasculature may contribute to the elevated SVR that is characteristic of the early stages of hypertension in African American compared with Caucasians.