Elevated Total Iron-Binding Capacity Is Associated with an Increased Risk of Celiac Disease.
Elevated Total Iron-Binding Capacity Is Associated with an Increased Risk of Celiac Disease.
复制标题
总铁结合能力升高与乳糜泻风险增加相关。
DOI：
10.1007/s10620-015-3791-9
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发表时间：
2015
影响因子：
3.1
通讯作者：
Garber,John
中科院分区：
文献类型：
--
作者：
Letner,Dorothea;Peloquin,Joanna;Durand,Jacquelyn;Rutherford,Anna;Yajnik,Vijay;Khalili,Hamed;Garber,John
一些证据表明，异常的铁稳态本身可能在乳糜泻的发展中起重要作用。目的：我们试图确定在乳糜泻诊断之前是否可以检测到铁状态异常，并了解铁指标改变与乳糜泻自然史之间的关系。方法在两家大型三级转诊医院进行病例对照研究。病例由乳糜泻患者组成，在诊断前评估其铁状态。每个病例根据年龄和性别与五名没有已知胃肠道疾病的对照组相匹配。收集诊断前1,1 - 3和3-5年的潜在协变量和实验室值信息。我们采用条件logistic回归评价铁指标对乳糜泻风险的影响。结果157例乳糜泻病例和695例对照。与TIBC正常的参与者相比，TIBC升高的患者患乳糜泻的年龄调整风险显著升高。TIBC每增加10 μg/dL，在诊断前1年、1 - 3年和3-5年内，乳糜泻的风险分别增加4.6%、3.8%和7.9%。诊断前TIBC升高的患者更容易出现肝酶异常和骨质疏松。结论TIBC升高与乳糜泻风险增加相关。对铁稳态改变的潜在作用的进一步研究可能会揭示导致乳糜泻发展的重要环境因素。
BackgroundSeveral lines of evidence suggest that abnormal iron homeostasis may itself play an important role in the development of celiac disease.AimWe sought to determine whether abnormalities in iron status could be detected prior to the diagnosis of celiac disease, and to understand the relationship between altered iron indices and the natural history of celiac disease.MethodsWe conducted a case–control study at two major tertiary referral hospitals. Cases were comprised of patients with celiac disease in whom iron status was assessed prior to the diagnosis. Each case was matched to five controls without known gastrointestinal disease according to age and sex. Information on potential covariates and laboratory values within 1, 1–3, and 3–5 years prior to diagnosis was collected. We used conditional logistic regression to evaluate the effect of iron indices on risk of celiac disease.ResultsWe identified 157 celiac cases and 695 matched controls. Compared to participants with normal TIBC, the age-adjusted risk of celiac disease was significantly elevated among patients with elevated TIBC. For each 10 μg/dL increase in TIBC, the risk of celiac disease increased by 4.6, 3.8, and 7.9 % within 1, 1–3, and 3–5 years prior to diagnosis, respectively. Patients with elevated pre-diagnosis TIBC were more likely to have abnormal liver enzymes and osteoporosis.ConclusionsElevated TIBC is associated with an increased risk of celiac disease. Further investigation into the potential role of altered iron homeostasis may uncover important environmental factors that contribute to the development of celiac disease.