Molecular weight independence of the effect of additive hyaluronic acid on the lubricating characteristics in synovial joints with experimental deterioration
Molecular weight independence of the effect of additive hyaluronic acid on the lubricating characteristics in synovial joints with experimental deterioration
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DOI：
10.1016/s0268-0033(98)00084-9
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发表时间：
1999-06-01
影响因子：
1.8
通讯作者：
Kanayama, T
中科院分区：
文献类型：
--
作者：
Mabuchi, K;Obara, T;Kanayama, T
Objective.评估分子量依赖性的润滑特性添加剂透明质酸在动物关节实验恶化。设计。兔膝关节的体外实验研究。羟乙磺酸被用作治疗骨关节炎的药物。然而，透明质酸的作用的分子量依赖性尚不清楚。利用机械臂在力控制下测量了14个兔膝关节的摩擦系数。检查的实验条件为：（1）完整的关节面;（2）用生理盐水清洗关节面后;（3）加入分子量分别为一百万道尔顿和二百万道尔顿的1%透明质酸溶液后。结果。通过向关节表面添加透明质酸，用盐水洗涤产生的增加的摩擦系数显著降低。无论透明质酸的分子量如何，都观察到这种效果。透明质酸在滑膜关节中的润滑特性不随分子量而改变。
Objective. To assess the molecular weight dependence of the lubricating characteristics of additive hyaluronic acid in animal joints with experimental deterioration.Design. An experimental study in rabbits stifles in vitro.Background. Hyaluronic acid is used as a drug for osteoarthritis. However, the molecular weight dependence of the effect of hyaluronic acid has been unclear.Methods. Using a robotic arm under force-control, frictional coefficients were measured in fourteen rabbit stifles. The experimental conditions examined were: (1) intact joint surfaces; (2) after the joint surfaces were washed with physiological saline; (3) after the addition of 1% hyaluronic acid solution with a molecular weight of one million daltons and two million daltons, respectively.Results. The increased frictional coefficient produced by washing with saline was decreased significantly by the addition of hyaluronic acid to the joint surfaces. This effect was observed regardless of the molecular weight of the hyaluronic acid.Conclusion. The lubricating characteristics of hyaluronic acid in synovial joints do not change with molecular weight.