Precipitated withdrawal during maintenance opioid blockade with extended release naltrexone
Precipitated withdrawal during maintenance opioid blockade with extended release naltrexone
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DOI：
10.1111/j.1360-0443.2008.02252.x
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发表时间：
2008-08-01
期刊：
影响因子：
6
通讯作者：
Fishman, Marc
中科院分区：
文献类型：
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作者：
Fishman, Marc
背景：使用缓释注射用纳洛酮治疗阿片类药物依赖的兴趣越来越大。病例描述我们报告了一例17岁的青少年女性接受延长释放纳洛酮（Vivitrol）治疗阿片类药物依赖后突然戒断的病例，在使用羟考酮并轻度中毒后几天，她连续第三次每月服用药物。结论这种情况表明，在某些情况下，阿片类药物的封锁可能会被克服时，纳洛酮水平下降接近结束的给药间隔，产生脆弱性，随后纳洛酮诱导的戒断。这可能为临床管理和给药策略提供警示性指导。
Background There has been increasing interest in the use of extended release injectable naltrexone for the treatment of opioid dependence. Case description We report a case of precipitated withdrawal in a 17-year-old adolescent female receiving extended release naltrexone (Vivitrol) for opioid dependence, following her third serial monthly dose of the medication, several days after using oxycodone with mild intoxication. Conclusions This case suggests that, in some circumstances, the opioid blockade may be overcome when naltrexone levels drop towards the end of the dosing interval, producing vulnerability to subsequent naltrexone-induced withdrawal. This may provide cautionary guidance for clinical management and dosing strategies.