Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs
Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs
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DOI：
10.1111/vsu.12768
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发表时间：
2018-04-01
影响因子：
1.8
通讯作者：
Buracco, Paolo
中科院分区：
文献类型：
--
作者：
Bennett, Tristram C.;Matz, Brad M.;Buracco, Paolo
目的探讨组织学证实的前列腺癌犬全前列腺切除术后的并发症及预后。研究设计：多机构回顾性病例系列。动物：客户拥有的狗。方法回顾2004 - 2016年接受全前列腺切除术的犬的医疗记录。检索的数据包括信号、表现体征、术前临床表现、实验室数据、诊断影像、手术技术、组织学诊断、术后并发症、术后转移发生率和生存率。结果25只前列腺癌犬行全前列腺切除术。泌尿吻合术包括尿道尿道吻合术14例，膀胱尿道吻合术9例，输尿管结肠吻合术1例，膀胱颈与阴茎尿道吻合术1例。所有的狗都存活下来出院了。15只狗被诊断为移行细胞癌，8只狗被诊断为前列腺腺癌，1只狗被诊断为前列腺囊腺癌，1只狗被诊断为未分化癌。23只狗中有8只出现永久性术后尿失禁。与囊内肿瘤相比，囊外肿瘤扩展犬的中位生存时间较短。总中位生存期为231天（范围24-1255天），1年和2年生存率分别为32%和12%。结论及临床意义：与以往报道的前列腺癌犬相比，全前列腺切除术联合辅助治疗可延长生存期，降低并发症发生率。然而，应该注意的是，病例选择可能在术后结果中起着重要作用。
ObjectiveTo describe the complications and outcome after total prostatectomy in dogs with histologically confirmed prostatic carcinoma.Study DesignMulti-institutional retrospective case series.Animals25 client-owned dogs.MethodsMedical records of dogs undergoing total prostatectomy were reviewed from 2004 to 2016. Data retrieved included signalment, presenting signs, preoperative clinical findings, laboratory data, diagnostic imaging, surgical technique, histologic diagnosis, postoperative complications, occurrence of postoperative metastasis, and survival.ResultsTwenty-five dogs underwent total prostatectomy for prostatic carcinoma. Urinary anastomotic techniques included urethrourethral anastomosis in 14 dogs, cystourethral anastomosis in 9 dogs, ureterocolonic anastomosis in 1 dog, and anastomosis between the bladder neck and penile urethra in 1 dog. All dogs survived to discharge. Fifteen dogs were diagnosed with transitional cell carcinoma, 8 dogs with prostatic adenocarcinoma, 1 with prostatic cystadenocarcinoma, and 1 with an undifferentiated carcinoma. Permanent postoperative urinary incontinence was present in 8 of 23 dogs. The median survival time was shorter in dogs with extracapsular tumor extension compared with those with intracapsular tumors. The overall median survival time was 231 days (range, 24-1255), with 1- and 2-year survival rates equal to 32% and 12%, respectively.Conclusion and Clinical SignificanceTotal prostatectomy, combined with adjunct therapies, prolongs survival and lowers complication rates compared to previous reports of dogs with prostatic carcinoma. It should be noted, however, that case selection likely played a significant role in postoperative outcome.