Presence of Natural Killer B Cells in Simian Immunodeficiency Virus-Infected Colon That Have Properties and Functions Similar to Those of Natural Killer Cells and B Cells but Are a Distinct Cell Population.
Presence of Natural Killer B Cells in Simian Immunodeficiency Virus-Infected Colon That Have Properties and Functions Similar to Those of Natural Killer Cells and B Cells but Are a Distinct Cell Population.
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感染猿免疫缺陷病毒的结肠中存在自然杀伤 B 细胞，其特性和功能与自然杀伤细胞和 B 细胞相似，但属于不同的细胞群。
DOI：
10.1128/jvi.00235-22
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发表时间：
2022-04-13
影响因子：
5.4
通讯作者：
Barker, Edward
中科院分区：
文献类型：
--
作者：
Cogswell, Andrew;Jo, Sungro;Ferguson, Natasha;Gupta, Kajal;Barker, Edward
关键词：
Here, we report the appearance of natural killer B (NKB) cells within the colon during simian immunodeficiency virus (SIV) infection of susceptible monkeys. Using RNA sequencing (RNAseq) and flow cytometry, we show that NKB cells are unique cells with features and functions of both NK and B cells. NKB cells express receptors and ligands found on B cells that are important for (i) antigen presentation; (ii) activities associated with class switching, affinity maturation, and B-cell memory formation in secondary lymphoid follicles; and (iii) antigen recognition. The predominant immunoglobulins (Igs) expressed on NKB cells are IgA, although NKB cells can express surface IgM and IgG. There is dominant lambda expression over the kappa light chain characteristic of mucosal B cells. In addition to B-cell aspects, NKB cells express NK cell activation receptors and Fas ligand. We show in this study that NKB cells express perforin and granzymes and lyse cells in a lytic assay. In addition to NK cell cytolytic function, NKB cells also produce the inflammatory cytokines interferon gamma, tumor necrosis factor alpha, and interleukin-18 (IL-18). Finally, we noted the increased capacity of NKB cells to proliferate compared to NK cells and CD8+ T cells from the SIV-infected colon. The increased proliferation and inflammatory cytokine production may be related to the relatively high expression levels of IL-15 receptor beta, IL-7 receptor, IL-18 receptor, and 41BB relative to the same receptors on CD8 and NK cells. The properties of NKB cells may point to their role in the enhanced inflammation observed in the SIV-infected gut. IMPORTANCE There is low-level but significant mucosal inflammation in the gastrointestinal tract secondary to human immunodeficiency virus (HIV) infection that has long-term consequences for the infected host. This inflammation most likely originates from the immune response that appears as a consequence of HIV. Here, we show in an animal model of HIV that the chronically SIV-infected gut contains cytotoxic natural killer B cells that produce inflammatory cytokines and proliferate during infection.
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影响因子：
82.9
作者：
Graham, W. Vallen;He, Weiqi;Turner, Jerrold R.
通讯作者：
Turner, Jerrold R.
自适应天然杀伤细胞在目标细胞相遇期间整合白介素18。
影响因子：
7.3
作者：
Hammer Q;Rückert T;Dunst J;Romagnani C
通讯作者：
Romagnani C
影响因子：
6.7
作者：
Estes JD;Harris LD;Klatt NR;Tabb B;Pittaluga S;Paiardini M;Barclay GR;Smedley J;Pung R;Oliveira KM;Hirsch VM;Silvestri G;Douek DC;Miller CJ;Haase AT;Lifson J;Brenchley JM
通讯作者：
Brenchley JM
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.4
作者：
Cogswell, Andrew;Ferguson, Natasha;Barker, Edward
通讯作者：
Barker, Edward