Lipophilin, a novel heterodimeric protein of human tears
Lipophilin, a novel heterodimeric protein of human tears
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DOI：
10.1016/s0014-5793(98)00852-7
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发表时间：
1998-08-07
期刊：
影响因子：
3.5
通讯作者：
Glasgow, BJ
中科院分区：
文献类型：
--
作者：
Lehrer, RI;Xu, GR;Glasgow, BJ
We identified a novel heterodimeric protein, lipophilin AC, in human tears. One of its components, lipophilin A (69 residues; mass, 7575.1; pI, 9.47) was homologous to the C1 and C2 components of prostatein ('estramustine-binding protein'), the major secreted protein of rat prostate. Human lipophilin C (77 residues; mass, 8854.1; pI, 4.94) was homologous to the rat prostatein C3 component and to human mammaglobin, a protein overexpressed in some mammary carcinomas. Tear lipophilins A and C expand the roster of human uteroglobin superfamily members and provide models for exploring these typically steroid-regulated and steroid-binding molecules. (C) 1998 Federation of European Biochemical Societies.
