Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments
Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments
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DOI：
10.1093/bioinformatics/btl151
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发表时间：
2006-06-15
期刊：
影响因子：
5.8
通讯作者：
Radivojac, Predrag
中科院分区：
文献类型：
--
作者：
Vacic, Vladimir;Iakoucheva, Lilia M.;Radivojac, Predrag
Two Sample Logo是一个基于网络的工具，可检测并显示两组多序列比对之间位置特定符号组成的统计学显著差异。在一个典型的情况下，两组比对序列将共享一个共同的基序，但在它们的功能注释上不同。包括背景比对提供了适当的潜在氨基酸或核苷酸分布，并解决了位点间符号相关性。此外，差异检测过程对对齐组的大小敏感。Two Sample Logo扩展了WebLogo，一个广泛使用的序列徽标生成器。源代码在MIT开源许可协议下分发，并可免费下载。
Two Sample Logo is a web-based tool that detects and displays statistically significant differences in position-specific symbol compositions between two sets of multiple sequence alignments. In a typical scenario, two groups of aligned sequences will share a common motif but will differ in their functional annotation. The inclusion of the background alignment provides an appropriate underlying amino acid or nucleotide distribution and addresses intersite symbol correlations. In addition, the difference detection process is sensitive to the sizes of the aligned groups. Two Sample Logo extends WebLogo, a widely-used sequence logo generator. The source code is distributed under the MIT Open Source license agreement and is available for download free of charge.