FDG-PET/CT imaging in assessing mucin-producing non-small cell lung cancer with pathologic correlation
FDG-PET/CT imaging in assessing mucin-producing non-small cell lung cancer with pathologic correlation
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DOI：
10.1007/s12149-010-0358-x
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发表时间：
2010-06-01
影响因子：
2.6
通讯作者：
Han, Joungho
中科院分区：
文献类型：
--
作者：
Shim, Sung Shine;Han, Joungho
目的本研究的目的是描述产生黏液的非小细胞肺癌（NSCLC）的PET/CT表现及其与病理的关系。方法对所有FDG-PET/CT患者进行回顾性分析，确定11例经组织病理学证实的粘液生成性非小细胞肺癌；本院发现黏液性细支气管肺泡癌（mBAC） 3例，黏液性BAC模式突出的混合型腺癌（ADENO + mBAC） 5例，产生黏液蛋白的混合型腺癌（ADENO + mucin） 3例。结果11例患者中，仅有2例（18%）病灶PET阳性，标准化摄取值（SUV）为3.5 （ROC分析），而所有病例CT均正确检测。未检测到的9个病变的平均SUV为2.0，所有病例的平均SUV为2.5。纯mBAC的平均SUV为1.93，产粘蛋白腺癌的平均SUV为2.69，两者差异无统计学意义（p = 0.279）。肿瘤大小或分期与SUV无显著相关性。结论PET/CT对产生黏液蛋白的非小细胞肺癌的检测有限。因此，PET/CT的CT组件可以显著提高灵敏度，并有助于减少延迟诊断。mBACs的SUV低于其他类型的粘液生成腺癌；然而，我们确定两组肺癌患者的suv之间没有显著差异。
Objective The objective of this study was to describe the PET/CT findings of mucin-producing non-small cell lung cancer (NSCLC) and how those findings are associated with pathology.Methods A review of all patients with FDG-PET/CT identified 11 patients with histopathologically confirmed mucin-producing NSCLC; 3 mucinous bronchioloalveolar carcinoma (mBAC), 5 mixed-type adenocarcinoma with prominent mucinous BAC pattern (ADENO + mBAC), and 3 mixed-type adenocarcinoma with mucin production (ADENO + MUCIN) in our institute.Results Among 11 patients, only 2 lesions (18%) evidenced positive PET results for standardized uptake value (SUV) of 3.5 (by ROC analysis) whereas all cases were detected correctly at CT. The mean SUV was 2.0 in the 9 lesions not detected and 2.5 in all cases. The mean SUV of pure mBAC was 1.93, that of mucin-producing adenocarcinoma was 2.69 without a significant difference (p = 0.279). No significant correlations between tumor size or stage and SUV were determined.Conclusions PET/CT for SUV is limited in the detection of mucin-producing NSCLC. Therefore, the CT component of PET/CT may allow for significantly improved sensitivity and help to reduce delayed diagnose. The SUV in mBACs were lower than the other types of mucin-producing adenocarcinoma; however, we determined no significant difference to exist between the SUVs of two groups of lung cancer.