Quantitative magnetic detection of finger movements in patients with Parkinson's disease
Quantitative magnetic detection of finger movements in patients with Parkinson's disease
复制标题
DOI：
10.1016/j.neures.2004.03.004
复制
发表时间：
2004-06-01
影响因子：
2.9
通讯作者：
Tsukada, K
中科院分区：
文献类型：
--
作者：
Kandori, A;Yokoe, M;Tsukada, K
为了开发一种新的定量检测帕金森病患者手指运动的测量工具，我们设计了一种由磁感应线圈、传感线圈和电路单元组成的磁感应系统。传感线圈检测随两个线圈之间距离变化的感应磁场，将检测到的信号在电路单元中解调，从而由振荡频率得到变化电压。为了得到将电压转换成距离的系数，我们测量了12名正常志愿者手指7个固定位置的输出电压。然后记录20名PD患者、6名年龄匹配的对照组和12名正常志愿者手指运动对应的电压差，持续30 s。为了研究手指运动的速度和加速度，我们从测量的位移波形中计算出它们的波形。我们还通过使用快速傅里叶变换（FFT）检测了敲击节奏的主频率。在Hoehn-Yahr （HY）阶段，各波形的平均幅值随疾病的加重而降低，而PD患者的平均叩击频率与该阶段无相关性。实验结果表明，该磁感应系统可以对手指运动进行定量评估。(C) 2004爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
To develop a new measurement tool for quantitatively detecting the finger movement of a patient with Parkinson's disease (PD), we designed a magnetic sensing system consisting of a magnetic induction coil, a sensing coil, and a circuit unit. The sensing coil detects the inducted magnetic field that varies with the distance between the two coils, and the detected signals are demodulated in the circuit unit in order to obtain the variation voltage from the oscillation frequency. To obtain a coefficient for converting voltage to distance, we measured the output voltages for seven fixed finger positions of 12 normal volunteers. The voltage differences corresponding to the finger movement in 20 PD patients, six age-matched controls, and 12 normal volunteers were then recorded for 30 s. To investigate the velocity and acceleration of the finger movement, we calculated their waveforms from the measured displacement waveform. We also detected the main frequency of the tapping rhythm by using a fast Fourier transform (FFT). The averaged amplitude of each waveform decreased with the disorder in the Hoehn-Yahr (HY) stage, while the averaged tapping frequency of PD patients did not have any correlation with this stage. It can be concluded that this magnetic sensing system can assess finger movement quantitatively. (C) 2004 Elsevier Ireland Ltd and The Japan Neuroscience Society. All rights reserved.