Inhibitors of nitric oxide production from the flowers of Angelica furcijuga:: Structures of hyuganosides IV and V
Inhibitors of nitric oxide production from the flowers of Angelica furcijuga:: Structures of hyuganosides IV and V
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DOI：
10.1248/cpb.53.387
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发表时间：
2005-04-01
影响因子：
1.7
通讯作者：
Yoshikawa, M
中科院分区：
文献类型：
--
作者：
Matsuda, H;Morikawa, T;Yoshikawa, M
The methanolic extract from the flowers of Angelica furcijuga K-ITAGAWA was found to inhibit nitric oxide production in lipopolysacc hand e-activated mouse peritoneal macrophages. From the methanolic extract, two new glycosides, hyuganosides IV and V, were isolated together with 28 known constituents. The structures of the new constituents were determined on the basis of chemical and physicochernical evidence. Furthermore, the inhibitory effects of I I coumarin constituents on nitric oxide production were examined. Among them, 3 '-angeloyl-cis-khellactone (IC50=82 mu m), (S)-(-)-oxypeucedanin (57 mu m), imperatorin (60 mu m), isoepoxypteryxin (53 mu m), and isopteryxin (8.8 mu m) showed inhibitory activity.
