A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction
A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction
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DOI：
10.1007/s12350-009-9106-9
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发表时间：
2009-10-01
影响因子：
2.4
通讯作者：
Cullom, S. James
中科院分区：
文献类型：
--
作者：
Venero, Carmelo V.;Heller, Gary V.;Cullom, S. James
核心脏病学领域受到图像质量和手术时间的限制。与迭代重建相结合的深度相关分辨率恢复算法的使用有望提高图像质量并减少采集时间。这项研究比较了采用深度相关分辨率恢复和迭代重建的Astonish算法与使用全时(FTA)和半时(HTA)数据的滤波反投影(FBP)。衰减校正包括散射校正和Astonish算法的结合也得到了评估。我们研究了187名来自三个核心脏病实验室的连续患者(132名进行了心导管检查，55名为低可能性冠心病患者)，这些患者以前曾接受过临床显示的静息/负荷~(99)m Sestamibi或Tetrofosmin SPECT。收购遵循ASNC的指导方针(预测，20-25秒)。全职数据集的处理包括FBP和Astonish(FTA)。通过剥离全时数据集并使用Astonish(HTA)进行处理，共生成32个投影数据集。对全时和半时Astonish处理的图像(分别为FTA-AC和HTA-AC)进行衰减校正。三位盲人对图像质量、解释的确定性、诊断的准确性以及血流灌注和功能参数的严重程度和可逆性进行了一致的解释，全时和半时Astonish处理的图像质量与FBP相比有显著改善。负荷和静息灌注图像质量(优或良)分别为85%/80%、98%/95%和95%/92%(P<；0.001)。解释确定性和诊断准确性与FBP、FTA和HTA相似。尽管半时间门控图像质量略有下降，但左心功能数据并无不同。应用衰减校正后，图像质量相似，正常度提高(FTA vs.FTA-AC：76%vs.95%；HTA vs.HTA-AC：76%vs.100%)和特异性(FTA vs.FTA-AC：62%vs.78%；HTA vs.HTA-AC：63%vs.84%)(p<；0.01)。Astonish处理结合了随深度变化的分辨率恢复，在不牺牲解释确定性或诊断准确性的情况下提高了图像质量。将同时获取的衰减校正(包括散射校正)应用于用该方法处理的全时和半时图像，在保持高图像质量的同时提高了特异度和正常度。
The field of nuclear cardiology is limited by image quality and length of procedure. The use of depth-dependent resolution recovery algorithms in conjunction with iterative reconstruction holds promise to improve image quality and reduce acquisition time. This study compared the Astonish algorithm employing depth-dependent resolution recovery and iterative reconstruction to filtered backprojection (FBP) using both full-time (FTA) and half-time (HTA) data. Attenuation correction including scatter correction in conjunction with the Astonish algorithm was also evaluated.We studied 187 consecutive patients (132 with cardiac catheterization and 55 with low likelihood for CAD) from three nuclear cardiology laboratories who had previously undergone clinically indicated rest/stress Tc-99m sestamibi or tetrofosmin SPECT. Acquisition followed ASNC guidelines (64 projections, 20-25 seconds). Processing of the full-time data sets included FBP and Astonish (FTA). A total of 32 projection data sets were created by stripping the full-time data sets and processing with Astonish (HTA). Attenuation correction was applied to both full-time and half-time Astonish-processed images (FTA-AC and HTA-AC, respectively). A consensus interpretation of three blinded readers was performed for image quality, interpretative certainty, and diagnostic accuracy, as well as severity and reversibility of perfusion and functional parameters.Full-time and half-time Astonish processing resulted in a significant improvement in image quality in comparison with FBP. Stress and rest perfusion image quality (excellent or good) were 85%/80% (FBP), 98%/95% (FTA), and 95%/92% (HTA), respectively (p < 0.001). Interpretative certainty and diagnostic accuracy were similar with FBP, FTA, and HTA. Left ventricular functional data were not different despite a slight reduction in half-time gated image quality. Application of attenuation correction resulted in similar image quality and improved normalcy (FTA vs. FTA-AC: 76% vs. 95%; HTA vs. HTA-AC: 76% vs. 100%) and specificity (FTA vs. FTA-AC: 62% vs. 78%; HTA vs. HTA-AC: 63% vs. 84%) (p < 0.01 for all comparisons).Astonish processing, which incorporates depth-dependent resolution recovery, improves image quality without sacrificing interpretative certainty or diagnostic accuracy. Application of simultaneously acquired attenuation correction, which includes scatter correction, to full-time and half-time images processed with this method, improves specificity and normalcy while maintaining high image quality.