SEROEPIDEMIOLOGIC STUDY OF ADENOVIRUS-ASSOCIATED VIRUS INFECTION IN INFANTS AND CHILDREN
SEROEPIDEMIOLOGIC STUDY OF ADENOVIRUS-ASSOCIATED VIRUS INFECTION IN INFANTS AND CHILDREN
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DOI：
10.1093/oxfordjournals.aje.a121331
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发表时间：
1971-01-01
影响因子：
5
通讯作者：
CHANOCK, RM
中科院分区：
文献类型：
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作者：
BLACKLOW, NR;HOGGAN, MD;CHANOCK, RM
Blacklow，N. R.（传染病实验室，NIAID，NIH，Bethesda，马里兰州20014），M. D.霍根，M. S.塞雷诺角D. Brandt，H. W.金河，巴西-地H.帕罗特和R. M.查诺克婴儿和儿童腺病毒相关病毒感染的血清流行病学研究。Amer J Epidem 94：359 - 366，1971。-作为一项为期8年的腺病毒呼吸道疾病对照研究的一部分，对551名住院儿童的配对血清进行了针对缺陷型腺病毒相关病毒（AAV）的补体结合（CF）抗体的研究。研究了三组患者：371名患有腺病毒感染相关呼吸道疾病的儿童; 90名临床上无感染性疾病的腺病毒阴性对照儿童;以及90名无症状的腺病毒感染对照儿童。每个类别中约30%的儿童具有2型和/或3型AAV的CF抗体;该百分比在研究的每一年都相似。32名血清转化为AAV-2和/或AAV-3的儿童中，除1名外，其余均显示近期腺病毒感染的证据。患有呼吸道疾病的腺病毒感染儿童中，血清转化为AAV-2和/或AAV-3的人数（30人）明显多于其他两类（每组1人）。肺炎、细支气管炎、哮吼和咽-支气管炎在AAV血清转化儿童中的发生频率与所有呼吸道疾病受试者大致相同。AAV血清转换患者倾向于显示与呼吸道疾病相关的腺病毒感染的病毒学和血清学特征。
Blacklow, N. R. (Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20014), M. D. Hoggan, M. S. Sereno, C. D. Brandt, H. W. Kim, R. H. Parrott and R. M. Chanock. A seroepidemiologic study of adenovirus-associated virus infection in infants and children.Amer J Epidem94: 359–366, 1971.—A search for complement-fixing (CF) antibodies to the defective adenovirus-associated viruses (AAV) has been performed on the paired sera of 551 hospitalized children as part of an 8-year controlled study of adenovirus respiratory illness. Three groups of patients were studied: 371 children with respiratory tract disease associated with adenovirus infection; 90 adenovirus-negative control children who were clinically free of infectious disease; and 90 adenovirus-infected control children who were asymptomatic. Approximately 30% of the children in each category possessed CF antibodies to AAV types 2 and/or 3; this percentage was similar for each year of the study. All but one of the 32 children with seroconversions to AAV-2 and/or AAV-3 showed evidence for a recent adenovirus infection. There was a significantly greater number (30) of adenovirus-infected children ill with respiratory tract disease with seroconversions to AAV-2 and/or AAV-3 than in either of the other 2 categories (1 in each group). Pneumonia, bronchiolitis, croup, and pharyngitis-bronchitis occurred at approximately the same frequency among children with an AAV seroconversion as among all subjects with respiratory illness. Patients with an AAV seroconversion tended to show the virologic and serologic features of adenovirus infections associated with respiratory tract disease.