DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts
DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts
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DOI：
10.2217/epi.15.22
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发表时间：
2015-01-01
期刊：
影响因子：
3.8
通讯作者：
Rutten, Bart P. F.
中科院分区：
文献类型：
--
作者：
Chouliaras, Leonidas;Kenis, Gunter;Rutten, Bart P. F.
表观遗传失调与认知能力下降和阿尔茨海默病有关。本研究在两个独立的轻度认知障碍患者的前瞻性队列中调查了调节DNA甲基化的基因中常见snp与认知能力下降的年龄相关变化之间的关系。DNMT3A中的rs1187120 SNP与认知功能的年度下降之间存在关联，这表明DNMT3A可以调节轻度认知障碍受试者的认知能力下降。
Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.