INCIDENCE OF HYPERTENSION AND STROKE IN RELATION TO BODY-FAT DISTRIBUTION AND OTHER RISK-FACTORS IN OLDER WOMEN
INCIDENCE OF HYPERTENSION AND STROKE IN RELATION TO BODY-FAT DISTRIBUTION AND OTHER RISK-FACTORS IN OLDER WOMEN
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DOI：
10.1161/01.str.21.5.701
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发表时间：
1990-05-01
期刊：
影响因子：
8.3
通讯作者：
MUNGER, RG
中科院分区：
文献类型：
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作者：
FOLSOM, AR;PRINEAS, RJ;MUNGER, RG
在41，837名年龄在55-69岁之间的女性队列中，研究了体脂分布（通过腰臀比测量）与2年高血压和中风发病率之间的关系。患有高血压的女性腰臀比处于上三分位数的可能性是未患高血压的女性的2.1倍（95%置信区间1.7-2.6）。校正年龄、体重指数（千克/平方米）、吸烟、体力活动、饮酒和教育水平后，该比值比降至1.6（95%置信区间1.3-2.1）。发生中风的女性腰臀比处于上三分位数的可能性也是未发生中风的女性的2.1倍（95%置信区间1.5-2.9）。对相同协变量的调整也将比值比降低至1.6（95%置信区间1.1-2.4）。进一步校正高血压和糖尿病可将腰臀比升高引起的卒中估计风险降低至1.3（95%置信区间0.8-2.1）。在多变量模型中，高血压、糖尿病和吸烟仍与卒中发病率显著相关。这些结果表明，腹部肥胖，如增加腰臀比，增加高血压和中风的风险，即使在占整体体重。腹型肥胖与中风风险的相关性部分与腹型肥胖与高血压和糖尿病的相关性有关。
The relation between body fat distribution, as measured by the waist-to-hip circumference ratio, and the 2-year incidence of hypertension and stroke were examined in a cohort of 41,837 women aged 55-69 years. Women who developed hypertension were 2.1 (95% confidence interval 1.7-2.6) times more likely to be in the upper tertile of waist-to-hip ratio than those who did not. Adjustment for age, body mass index (kilograms per meter squared), cigarette smoking, physical activity, alcohol intake, and education level reduced this odds ratio to 1.6 (95% confidence interval 1.3-2.1). Women who developed a stroke were also 2.1 (95% confidence interval 1.5-2.9) times more likely to be in the upper tertile of waist-to-hip ratio than those who did not. Adjustment for the same covariates also lowered this odds ratio to 1.6 (95% confidence interval 1.1-2.4). Further adjustment for hypertension and diabetes mellitus reduced the estimated risk of stroke due to elevated waist-to-hip ratio to 1.3 (95% confidence interval 0.8-2.1). Hypertension, diabetes mellitus, and cigarette smoking remained significantly associated with stroke incidence in the multivariate model. These results indicate that abdominal adiposity, as measured by an increased waist-to-hip ratio, increases the risks of hypertension and stroke, even after accounting for overall body mass. The association of abdominal adiposity with risk of stroke is related, in part to the association of abdominal adiposity with hypertension and diabetes.