Gene: a gene-centered information resource at NCBI
Gene: a gene-centered information resource at NCBI
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DOI：
10.1093/nar/gku1055
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发表时间：
2015-01-28
影响因子：
14.9
通讯作者：
Murphy, Terence D.
中科院分区：
文献类型：
--
作者：
Brown, Garth R.;Hem, Vichet;Murphy, Terence D.
国家生物技术信息中心(NCBI)的基因数据库(www.ncbi.nlm.nih.gov/gene)集成了来自多个数据源的特定基因信息。病毒、原核生物和真核生物的NCBI参考序列(RefSeq)基因组是基因记录的主要基础，因为它们形成了序列和被跟踪基因之间的关键联系，而被跟踪的基因是额外的功能和描述性内容的锚定。其他内容是基于基因组位置和RefSeq转录本和蛋白质序列数据整合的。基因记录的内容代表来自RefSeq、协作模式生物体数据库、诸如基因本体论的联盟以及NCBI内的其他数据库的管理和自动化处理的集成。基因中的记录被指定为唯一的、被跟踪的整数作为标识符。内容(引文、命名、基因组位置、基因产品及其属性、表型、序列、相互作用、变异细节、图谱、表达、同源、蛋白质结构域和外部数据库)可通过NCBI的Entrez系统交互浏览、通过NCBI的Entrez编程实用程序(E-Utilities和Entrez Direct)获取，也可通过FTP批量传输。
The National Center for Biotechnology Information's (NCBI) Gene database (www.ncbi.nlm.nih.gov/gene) integrates gene-specific information from multiple data sources. NCBI Reference Sequence (RefSeq) genomes for viruses, prokaryotes and eukaryotes are the primary foundation for Gene records in that they form the critical association between sequence and a tracked gene upon which additional functional and descriptive content is anchored. Additional content is integrated based on the genomic location and RefSeq transcript and protein sequence data. The content of a Gene record represents the integration of curation and automated processing from RefSeq, collaborating model organism databases, consortia such as Gene Ontology, and other databases within NCBI. Records in Gene are assigned unique, tracked integers as identifiers. The content (citations, nomenclature, genomic location, gene products and their attributes, phenotypes, sequences, interactions, variation details, maps, expression, homologs, protein domains and external databases) is available via interactive browsing through NCBI's Entrez system, via NCBI's Entrez programming utilities (E-Utilities and Entrez Direct) and for bulk transfer by FTP.