Surgical removal vs observation for idiopathic or ocular histoplasmosis syndrome-associated subfoveal choroidal neovascularization: Vision Preference Value Scale findings from the randomized SST Group H Trial: SST Report No. 17.
Surgical removal vs observation for idiopathic or ocular histoplasmosis syndrome-associated subfoveal choroidal neovascularization: Vision Preference Value Scale findings from the randomized SST Group H Trial: SST Report No. 17.
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DOI：
10.1001/archopht.126.12.1626
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发表时间：
2008-12
影响因子：
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通讯作者：
E. Bass;Marta M. Gilson;C. Mangione;B. Hawkins;Päivi H. Miskala;Ashley L. Mann;N. Bressler
中科院分区：
文献类型：
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作者：
E. Bass;Marta M. Gilson;C. Mangione;B. Hawkins;Päivi H. Miskala;Ashley L. Mann;N. Bressler
目的：观察和手术治疗特发性或与组织浆菌病相关的中央凹下脉络膜新生血管患者在健康和视力状况方面的偏好值是否存在差异。方法入组前后，患者对自己目前的视力进行0（失明）到100（完美视力）的评分，对失明和完美视力进行0（死亡）到100（完美健康和视力）的评分。当前视力的得分被转换为偏好值量表（0代表死亡；100代表完美的健康和视力）。结果在170例患者中，观察组和手术组在基线（74 vs 70）、12个月（74 vs 78）或24个月随访（77 vs 73）时的中位视力偏好值无显著差异（P < 0.05）。对于年龄、单侧与双侧脉络膜新生血管、基线视力好与基线视力差的亚组，两组间的偏好值没有差异。结论：尽管先前报道的视力特异性生活质量有所改善，但黄斑下手术在患者健康状况的偏好值方面并不优于观察。试验注册（clinicaltrials.gov）标识符：NCT00000150。临床意义眼科医生在确定与黄斑下手术试验H组试验相似的患者的治疗方法时，应考虑对不同生活质量指标的影响。
OBJECTIVE To determine whether patients receiving observation vs surgery for subfoveal choroidal neovascularization that was idiopathic or associated with histoplasmosis differed in preference values assigned to their health and vision status. METHODS Before and after enrollment, patients rated their current vision on a scale from 0 (blind) to 100 (perfect vision) and rated blindness and perfect vision on a scale from 0 (dead) to 100 (perfect health and vision). Scores for current vision were converted to a preference value scale (0 represents death; 100, perfect health and vision). RESULTS In 170 patients, no significant difference existed between the observation and surgery arms in median vision preference values at baseline (74 vs 70) or at the 12- (74 vs 78) or 24-month follow-up (77 vs 73) (P > .05). Preference values did not differ between arms for subgroups defined by age, unilateral vs bilateral choroidal neovascularization, or good vs poor baseline visual acuity. CONCLUSIONS Submacular surgery was no better than observation in the preference values patients assigned to their health status, despite previously reported improvements in vision-specific quality of life. TRIAL REGISTRATION (clinicaltrials.gov) Identifier: NCT00000150. CLINICAL RELEVANCE Ophthalmologists should consider the effects on different measures of quality of life when determining treatment for patients similar to those in the Submacular Surgery Trials Group H Trial.