TRP channels in disease.
TRP channels in disease.
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DOI：
10.1007/978-1-4020-6191-2_9
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发表时间：
2007
影响因子：
--
通讯作者：
S. Jordt;B. Ehrlich
中科院分区：
文献类型：
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作者：
S. Jordt;B. Ehrlich
瞬时受体电位（TRP）通道是一个大家族的蛋白质，具有六个主要亚家族，称为TRPC（典型），TRPV（香草素），TRPM（melastatin），TRPP（多囊蛋白），TRPML（粘磷脂）和TRPA（锚蛋白）组。具有不同功能的不同TRP的绝对数量支持以下陈述：这些通道参与范围广泛的过程，从热和化学信号的感测到响应细胞外刺激后重新加载细胞内存储。TRP的突变与病理生理学和特定疾病有关。对TRP在正常生理学中的作用的理解才刚刚开始;从TRP突变到病理生理学和疾病的进展将随之而来。在这篇综述中，我们集中在TRP通道生理学的两个不同方面，TRP通道在细胞内Ca 2+稳态中的作用，以及它们在感觉神经元中疼痛刺激的转导中的作用
The transient receptor potential (TRP) channels are a large family of proteins with six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) groups. The sheer number of different TRPs with distinct functions supports the statement that these channels are involved in a wide range of processes ranging from sensing of thermal and chemical signals to reloading intracellular stores after responding to an extracellular stimulus. Mutations in TRPs are linked to pathophysiology and specific diseases. An understanding of the role of TRPs in normal physiology is just beginning; the progression from mutations in TRPs to pathophysiology and disease will follow. In this review, we focus on two distinct aspects of TRP channel physiology, the role of TRP channels in intracellular Ca2+homeostasis, and their role in the transduction of painful stimuli in sensory neurons