Effect of percutaneous androgen replacement therapy on body composition and body weight in postmenopausal women
Effect of percutaneous androgen replacement therapy on body composition and body weight in postmenopausal women
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DOI：
10.1016/s0378-5122(98)00031-0
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发表时间：
1998-06-17
期刊：
影响因子：
4.9
通讯作者：
Huber, JC
中科院分区：
文献类型：
--
作者：
Gruber, DM;Sator, MO;Huber, JC
目的：探讨局部雄激素替代治疗对绝经后妇女体重、体成分和脂肪分布的影响。方法：对39例体重增加的健康绝经后妇女(51.4+/-2.24岁)进行为期6个月的前瞻性研究。采用双能X线骨密度仪(DXA)测量体成分(脂肪质量，kg，%)。还测量了激素和血脂参数。受试者被分成两组。将雄激素凝胶(A组)或安慰剂凝胶(P组)局部应用于腹部和臀部-股骨区域。在局部治疗开始前和6个月后进行DXA检查。结果：A组总体重由68.0±13.1 kg降至65.4±11.8 kg，差异有非常显著意义(P<0.05)。腹部脂肪(37.3+/-11.2%至35.1+/-9.7%)、臀股脂肪(46.3+/-6.6%至45.4+/-7.7%)、全身脂肪(38.2+/-7.9%至36.1+/-8.6%)和BMI(24.8+/-4.3%至23.7+/-3.8)也显著降低。在安慰剂组中，体重(Kg)和体脂(%)没有明显的下降。A组血清总睾酮显著升高(0.29±0.24 ng/ml至0.72±0.17 ng/ml)，但对血脂指标无明显影响。结论：在有不明原因体重增加的绝经后妇女中，局部应用雄激素能够减少腹部脂肪堆积和总体重。与全身应用雄激素相比，局部给药对血脂水平没有影响。然而，臀部脂肪不太受雄激素的影响。(C)1998爱思唯尔爱尔兰科学有限公司。保留所有权利。
Objectives: This study was carried out to assess the effect of topical androgen replacement therapy on body weight, body composition and fat distribution in postmenopausal women. Methods: 39 healthy postmenopausal women (51.4 +/- 2.24 years), with increasing body weight, were prospectively studied for 6 months. Body composition (fat mass, kg, %) was measured by means of dual-energy X-ray absorptiometry (DXA). Hormonal and lipid parameters were also measured. Subjects were divided into two groups. An androgen gel (group A) or placebo gel (group P) was topically administered to the abdominal and gluteo-femoral regions. DXA was performed before commencement of topical treatment and after 6 months. Results: A highly significant total body weight reduction was found in group A (68.0 +/- 13.1 to 65.4 +/- 11.8 kg). Abdominal fat (37.3 +/- 11.2 to 35.1 +/- 9.7%), gluteo-femoral fat (46.3 +/- 6.6 to 45.4 +/- 7.7%), total body fat (38.2 +/- 7.9 to 36.1 +/- 8.6%) and BMI (24.8 +/- 4.3 to 23.7 +/- 3.8) were also found to have decreased significantly in this group. No significant reduction in body weight (kg) and body fat (%) could be measured in the placebo group. No influence on lipid parameters was found although total testosterone increased significantly in group A (0.29 +/- 0.24 to 0.72 +/- 0.17 ng/ml). Conclusions: Topically applied androgen is capable of reducing abdominal fat accumulations as well as total body weight in postmenopausal women with unexplained weight gain. In contrast to systemic androgen application, topical administration has no effect on the lipid profile. Gluteal fat, however, is less effectively influenced by androgens. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.