Akt2 expression correlates with prognosis of human hepatocellular carcinoma.
Akt2 expression correlates with prognosis of human hepatocellular carcinoma.
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DOI：
10.3892/or.11.1.25
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发表时间：
2004
期刊：
影响因子：
4.2
通讯作者：
Xundi Xu;M. Sakon;H. Nagano;N. Hiraoka;Hirofumi Yamamoto;N. Hayashi;K. Dono;S. Nakamori;K. Umeshita
中科院分区：
文献类型：
--
作者：
Xundi Xu;M. Sakon;H. Nagano;N. Hiraoka;Hirofumi Yamamoto;N. Hayashi;K. Dono;S. Nakamori;K. Umeshita
Akt是磷脂酰肌醇-3激酶的下游靶点，在肿瘤发生中起着多种作用。为了阐明Akt蛋白在肝癌发生中的作用，我们采用免疫组化方法检测了56例肝细胞癌（HCC）患者肿瘤组织和非肿瘤组织中Akt蛋白（Akt 1和Akt 2）的表达。Akt 2高表达21例（38%），Akt 1均为中等或低表达。Akt 2的低表达与组织病理学分化、门脉浸润和肿瘤结节数量相关（分别为p=0.026、0.023和0.001）。单变量分析显示，Akt 2、组织病理学分化和门静脉浸润是显著的预后因素（分别为p=0.001、0.028和0.006）。多变量分析显示，除了组织病理学分化，Akt 2是一个独立的预后标志物（癌症复发的风险比，6.35，p=0.012）。相反，Akt 1表达与任何临床病理特征无关。我们的研究结果表明，Akt 2，而不是Akt 1，是一个新的独立的预测肝癌的发展和进展。
Akt, a down-stream target of phosphatidylinositol-3 kinase, plays multiple roles in carcinogenesis. To elucidate its role in hepatocarcinogenesis, we immunohistochemically investigated the expression of Akt protein (Akt1 and Akt2) in tumor and non-tumor tissues from 56 patients with hepatocellular carcinoma (HCC). High expression of Akt2 in HCC tissues was detected in 21 cases (38%) while Akt1 expression was moderate or less in all cases. Low expression of Akt2 was associated with histopathological differentiation, portal invasion and number of tumor nodules (p=0.026, 0.023, and 0.001, respectively). Univariate analysis showed that Akt2, histopathological differentiation, and portal vein invasion were significant prognostic factors (p=0.001, 0.028, and 0.006, respectively). Multivariate analysis revealed that in addition to histopathological differentiation, Akt2 was an independent prognostic marker (risk ratio for cancer relapse, 6.35, p=0.012). In contrast, Akt1 expression did not correlate with any clinicopathological features. Our findings suggest that Akt2, but not Akt1, is a novel independent predictor for the development and progression of HCC.