Analysis of volume MRI and MR spectroscopic imaging data for the evaluation of patients with brain tumors
Analysis of volume MRI and MR spectroscopic imaging data for the evaluation of patients with brain tumors
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DOI：
10.1002/mrm.1183
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发表时间：
2001-08-01
影响因子：
3.3
通讯作者：
Nelson, SJ
中科院分区：
文献类型：
--
作者：
Nelson, SJ
体积磁共振成像和多体素定位磁共振波谱成像(MRSI)数据的结合为量化组织形态和功能的变化提供了可能性。这些技术在评估神经疾病方面有许多应用。虽然最先进的全身磁共振扫描仪能够获取这两种类型的数据，但介绍该技术临床应用的报告相对较少。其中一个原因是需要开发软件来重建和可靠地解释3D成像和光谱数据。在这篇文章中，我们描述了对脑肿瘤患者的MRI和MRSI联合检查进行定量分析的策略，并使用模拟和来自幻影、正常志愿者和患者的经验数据来评估这一过程的关键组件。重要的因素是使用体积或交错的多层解剖图像作为参考，重建和校正频谱数据的频率、相位和基线失真，以及考虑线圈的特性、用于空间选择的RIF脉冲和相位编码程序。这些研究表明，对区分肿瘤与正常组织和坏死组织最关键的代谢参数是胆碱和NAA的相对水平。肌酸和乳酸的水平被发现是不同的，就其在单个病变内和不同患者之间的空间分布而言。(C)2001年Wiley-Liss，Inc.
The combination of volumetric MRI and multivoxel localized MR spectroscopic imaging (MRSI) data provides the potential for quantifying variations in tissue morphology and function. These techniques have numerous applications for the evaluation of neurological diseases. While state-of-the-art whole-body MR scanners are able to acquire both types of data, there have been relatively few reports which have presented clinical applications of the technology. One of the reasons for this has been the need to develop software for reconstruction and reliable interpretation of 3D imaging and spectral data. In this article, we describe the strategy developed for quantitative analysis of combined MRI and MRSI examinations from patients with brain tumors and evaluate the key components of this procedure using both simulations and empirical data from phantoms, normal volunteers, and patients. Important factors are the use of volume or interleaved multislice anatomic images as a reference, the reconstruction and correction of the spectral data for frequency, phase, and baseline distortions and consideration of the characteristics of the coil, RIF pulses used for spatial selection, and phase encoding procedures. These studies show that the metabolic parameters most critical for distinguishing tumor from normal and necrotic tissue were relative levels of choline and NAA. Levels of creatine and lactate were found to be variable, both in terms of their spatial distribution within individual lesions and between different patients. (C) 2001 Wiley-Liss, Inc.