Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes in Nigerian patients with duodenal ulcer disease.
Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes in Nigerian patients with duodenal ulcer disease.
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尼日利亚十二指肠溃疡病患者幽门螺杆菌 vacA、cagA 和iceA 基因型的患病率。
DOI：
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发表时间：
2002
影响因子：
3
通讯作者：
S. Miehlke
中科院分区：
文献类型：
--
作者：
S. Smith;C. Kirsch;K. Oyedeji;A. Arigbabu;A. Coker;E. Bayerdöffer;S. Miehlke
幽门螺杆菌的独特毒力因子与感染的临床结果相关；然而，不同地理区域的情况存在很大差异。有关非洲幽门螺杆菌分离株基因型的数据很少。本研究的目的是确定尼日利亚十二指肠溃疡和非溃疡性消化不良患者中幽门螺杆菌特定基因型的患病率。幽门螺杆菌是从 41 名尼日利亚患者（19 名十二指肠溃疡，22 名非溃疡性消化不良）的内窥镜活检中培养出来的。通过PCR确定vacA等位基因、cagA和iceA基因型。十二指肠溃疡和非溃疡性消化不良患者的幽门螺杆菌分离株中，vacA s1,m1 和 s1,m2 基因型分别占 26.3% 和 22.7%，73.7% 和 72.7%。十二指肠溃疡和非溃疡性消化不良患者的分离株中分别有 94.7% 和 86.4% 存在iceA1 基因型。无论临床诊断如何，cagA+ 感染主要（> 90%）在尼日利亚幽门螺杆菌分离株中发现。总之，vacA s1、m2、iceA1和cagA+是从尼日利亚患者中分离出的幽门螺杆菌的常见基因型。与其他几个发展中国家一样，这些基因型与十二指肠溃疡病之间似乎没有关联。
Distinct virulence factors of Helicobacter pylori have been associated with clinical outcome of the infection; however, considerable variations have been reported from different geographic regions. Data on genotypes of African H. pylori isolates are sparse. The aim of this study was to determine the prevalence of specific genotypes of H. pylori in Nigerian patients with duodenal ulcer and non-ulcer dyspepsia. H. pylori was cultured from endoscopic biopsies obtained from 41 Nigerian patients (19 with duodenal ulcer, 22 with non-ulcer dyspepsia). The vacA alleles, cagA and iceA genotypes were determined by PCR. The vacA s1,m1 and s1,m2 genotypes were found in 26.3% and 22.7%, and in 73.7% and 72.7% of H. pylori isolates from patients with duodenal ulcer and non-ulcer dyspepsia, respectively. The iceA1 genotype was present in 94.7% and 86.4% of isolates from duodenal ulcer and non-ulcer dyspepsia patients, respectively. cagA+ infection was found predominantly (> 90%) in Nigerian H. pylori isolates irrespective of the clinical diagnosis. In conclusion, vacA s1,m2, iceA1 and cagA+ are common genotypes of H. pylori isolated from Nigerian patients. As in several other developing countries there seems to be no association between these genotypes and duodenal ulcer disease.
影响因子：
29.4
作者：
Atherton, JC;Peek, RM;Blaser, MJ
通讯作者：
Blaser, MJ
DOI：
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发表时间：
1996-07
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
S. Miehlke;K. Kibler;Jong G. Kim;N. Figura;Small Sm;D. Y. Graham;M. Go
通讯作者：
S. Miehlke;K. Kibler;Jong G. Kim;N. Figura;Small Sm;D. Y. Graham;M. Go
DOI：
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发表时间：
1998
期刊：
Proceedings of the Association of American Physicians
影响因子：
--
作者：
R. Peek;S. Thompson;J. Donahue;K. Tham;J. Atherton;M. Blaser;Geraldine G. Miller
通讯作者：
R. Peek;S. Thompson;J. Donahue;K. Tham;J. Atherton;M. Blaser;Geraldine G. Miller