The role of aflatoxin-contaminated food materials and HCV in developing hepatocellular carcinoma in Al-Sharkia Governorate, Egypt.
The role of aflatoxin-contaminated food materials and HCV in developing hepatocellular carcinoma in Al-Sharkia Governorate, Egypt.
复制标题
黄曲霉毒素污染的食品原料和 HCV 在埃及 Al-Sharkia 省发生肝细胞癌中的作用。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
M. Saber
中科院分区：
文献类型：
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作者：
M. S. Hifnawy;A. Mangoud;M. Eissa;Essam Nor Edin;Y. Mostafa;Yousry Abouel;Essam I Sabee;I. Amin;A. Ismail;T. Morsy;Seham Mahrous;Afefy F Afefy;eman el;Mohamoud el;H. Ragab;M. Hassan;Gaber el;M. Saber
Aflatoxins, particularly aflatoxin B1 (AFB1) have been recognized as one of the most potent chemical carcinogen. In Egypt, HCV is prevalent. The progressive nature of HCV-related liver diseases was found to be influenced by other factors. In this paper, the role of aflatoxin contamination in the onset of liver cancer in HCV-infected patients was studied. The quantitative identification of the possible aflatoxins contamination in six urban and eleven rural areas using high performance liquid chromatography technique, revealed that corn, wheat, pea nut, lupine "termis", white rice, cowpea "lobiya", fava bean and brown rice showed the prevalence of AFB1 to be 64.7%, 53%, 53%, 47%, 47%, 41%, 29.4% & 29.4% respectively. A positive correlation was found between aflatoxin and positive HCV-PCR together with liver disease progression to G3S3, the indicative of hepatocellular carcinoma. Such correlation was not fully understood, but the oncogene amplification caused by HCV-infection may be aggravated by the consumption of aflatoxin contaminated raw food materials or their products.
DOI：
10.1002/nt.2620030407
发表时间：
1995-01-01
期刊：
Natural Toxins
影响因子：
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作者：
Phillips, Timothy D.;Sarr, A. Bashir;Grant, Patrick G.
通讯作者：
Grant, Patrick G.