Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer.
Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer.
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DOI：
10.3748/wjg.v11.i44.6905
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发表时间：
2005-11
影响因子：
4.3
通讯作者：
T. Shishido;Taketo Yamaguchi;T. Odaka;Masanori Seimiya;H. Saisho;F. Nomura
中科院分区：
文献类型：
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作者：
T. Shishido;Taketo Yamaguchi;T. Odaka;Masanori Seimiya;H. Saisho;F. Nomura
目的探讨血清蔗糖通透性试验对胃部疾病的诊断价值，特别是对早期胃癌的诊断价值。方法研究对象为63例患者，其中胃溃疡11例，胃癌20例(早期13例，晚期7例)，健康对照组32例。分别在蔗糖负荷前和蔗糖负荷后5h内重复采集血、尿标本。用一种新开发的酶法测定蔗糖水平。结果胃病组大鼠血清蔗糖水平在负荷后15min开始升高，60min达到高峰。胃溃疡、上皮性胃炎和进展期胃癌60min时的水平显著高于健康对照组(分别为26.9±2.4、34.4±5.0和71.8±15.6vs7.9+/-0.7mol/L，P<；0.01)。以15.4mol/L(60min)为临界值时，EGC患者与正常对照组的敏感性和特异性分别为92.3%和93.8%，尿法分别为76.9%和93.8%。结论血清胃通透性试验对EGC的检测是可靠的，且比传统的尿液试验更早得到结果。这项检查可能为EGC的更具侵入性的检查提供一种有用的替代方法。
AIM To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer (EGC). METHODS A total of 63 subjects, including 11 patients with gastric ulcer, 20 patients with gastric cancer (13, early; 7, advanced) and 32 healthy controls, were studied. Blood and urine samples were collected repeatedly for 5 h before and after the sucrose loading. Sucrose levels were measured by a newly developed enzymatic method. RESULTS Serum sucrose levels started to increase 15 min after loading, and peaked at 60 min in the gastric disease groups. The levels for gastric ulcer, EGC and advanced gastric cancer (AGC) at 60 min were significantly higher than that in the healthy controls (26.9+/-2.4, 34.4+/-5.0, and 71.8+/-15.6 vs 7.9+/-0.7 mol/L, respectively, P<0.01). The cut-off level set at 15.4 mol/L (60 min) offered the best distinction between EGC patients and healthy controls; and the sensitivity and specificity were 92.3% and 93.8%, respectively, while those of the urine method were 76.9% and 93.8%, respectively. CONCLUSIONS The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC.