Targeting cancer stem cells in cancer prevention and therapy
Targeting cancer stem cells in cancer prevention and therapy
复制标题
DOI：
10.1007/s12015-008-9037-x
复制
发表时间：
2008-09-01
期刊：
影响因子：
--
通讯作者：
Srinivasan, Roopa
中科院分区：
文献类型：
--
作者：
Rajan, Prithi;Srinivasan, Roopa
癌症干细胞假说是一个吸引人的框架，人们可以在这个框架内考虑癌症的起始、复发和转移，以及制定癌症治疗策略的方法。尽管所有癌症似乎都不能依靠癌症干细胞维持生存，但也通过优势细胞群维持，创造包括癌症干细胞为靶点的癌症治疗策略似乎是合理的。从这个角度出发，我们讨论了控制癌症干细胞活性和致瘤性的可能策略，并将我们的讨论扩展到接近癌症预防的策略。
The cancer stem cell hypothesis is an attractive framework within which one may think about cancer initiation, recurrence, and metastasis, and methods to devise treatment strategies for cancers. Although all cancers do not appear to sustain themselves with cancer stem cells, but also through a dominant cell population, creating strategies for cancer treatment which include cancer stem cells as targets seems reasonable. In this perspective we discuss possible strategies for controlling the viability and tumorigenecity of cancer stem cells, and extend our discussion to strategies approaching the prevention of cancer.