EFFECTS OF SUCCESSIVE ENVIRONMENTS ON BRAIN MEASURES
EFFECTS OF SUCCESSIVE ENVIRONMENTS ON BRAIN MEASURES
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DOI：
10.1016/0031-9384(74)90212-1
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发表时间：
1974-01-01
影响因子：
2.9
通讯作者：
HEBERT, M
中科院分区：
文献类型：
--
作者：
BENNETT, EL;ROSENZWEIG, MR;HEBERT, M
为了测试差异经验诱导的大脑效应的持久性，将同窝出生的大鼠置于丰富的环境（EC）或贫困的环境（IC）中30或80天。在此初始阶段后，将每窝大鼠中的一只从EC条件转移至IC条件，而其同窝大鼠仍处于EC或IC条件下。第二阶段持续7、14、21、32或47天。当动物被置于一个共同的环境中时，由差异经验引起的大脑差异开始消失，但在诱导条件结束后的几周内，统计学上的显著差异仍然存在。初次接触80天后的持久性比接触30天后的持久性大。在EC 80天后，脑重量差异的显着持久性被发现21天后，从EC到IC删除;乙酰胆碱酯酶和胆碱酯酶活性的差异显着持久性被发现47天后。不同的大脑区域和不同的测量方法显示出不同的结果模式。在三个实验室中设计的三种不同的环境富集，比较了它们对脑重量和脑酶的影响。
To test the persistence of cerebral effects induced by differential experience, littermate rats were placed in an enriched environment (EC) or an impoverished environment (IC) for either 30 or 80 days. Following this initial period, one rat of each litter was transferred from the EC to IC condition while its littermates remained in EC or IC. The second phase lasted either 7, 14, 21, 32 or 47 days. The cerebral differences induced by differential experience began to dissipate when the animals were placed in a common environment, but statistically significant differences still persisted weeks after the end of the inducing conditions. Greater persistence was found after 80 days of initial exposure than after 30 days. Following 80 days in EC, significant persistence of brain weight differences was found 21 days after removal from EC to IC; significant persistence of differences in acetylcholinesterase and cholinesterase activities were found 47 days later. Different brain regions and different measures showed somewhat different patterns of results. Three different kinds of environmental enrichment — devised in three laboratories — were compared for their effects on brain weights and brain enzymes.