Curcumin prevents chronic alcohol-induced liver disease involving decreasing ROS generation and enhancing antioxidative capacity
Curcumin prevents chronic alcohol-induced liver disease involving decreasing ROS generation and enhancing antioxidative capacity
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DOI：
10.1016/j.phymed.2011.12.006
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发表时间：
2012-04-15
期刊：
影响因子：
7.9
通讯作者：
Liu, Liegang
中科院分区：
文献类型：
--
作者：
Rong, Shuang;Zhao, Yanting;Liu, Liegang
我们前期的研究发现，姜黄的主要活性成分姜黄素在体外能够改善乙醇诱导的肝细胞氧化应激。本研究的目的是探讨姜黄素对慢性酒精性肝病（ALD）的体内作用。暴露于乙醇的Balb/c小鼠（最初4周为2.4 g/kg/天乙醇，另外2周为4 g/kg/天）同时用姜黄素治疗6周。结果表明，姜黄素能减轻乙醇所致的肝组织病理学改变，并能明显改善细胞内丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）的释放。乙醇暴露导致活性氧（ROS）的产生，丙二醛（MDA）的升高，谷胱甘肽（GSH）耗尽和抗氧化防御系统的损害，姜黄素治疗显着逆转。总之，姜黄素对慢性ALD具有保护作用，其机制可能与减轻氧化损伤有关。Crown版权所有（C）2011由Elsevier GmbH发布。All rights reserved.
Our previous study found that curcumin, a major active component of turmeric, could ameliorate ethanol-induced hepatocytes oxidative stress in vitro. The objective of this work was to investigate the effect of curcumin on chronic alcoholic liver disease (ALD) in vivo. Ethanol-exposed (2.4 g/kg/day ethanol for the initial 4 weeks and 4 g/kg/day for another 2 weeks) Balb/c mice were simultaneously treated with curcumin for 6 weeks. The results showed that curcumin attenuated ethanol-induced histopathological changes of the liver and ameliorated the evident release of cellular alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Ethanol exposure resulted in reactive oxygen species (ROS) generation, malondialdehyde (MDA) elevation, glutathione (GSH) depletion and antioxidant defense system impairment, which were significantly reversed by curcumin treatment. In conclusion, curcumin provided protection against chronic ALD and the mechanism might be related to the alleviation of oxidative damage. Crown Copyright (C) 2011 Published by Elsevier GmbH. All rights reserved.