Wireless programmable electrochemical drug delivery micropump with fully integrated electrochemical dosing sensors.
Wireless programmable electrochemical drug delivery micropump with fully integrated electrochemical dosing sensors.
复制标题
无线可编程电化学药物输送微型泵，配有完全集成的电化学剂量传感器。
DOI：
10.1007/s10544-015-9980-7
复制
发表时间：
2015
影响因子：
2.8
通讯作者：
Meng,Ellis
中科院分区：
文献类型：
--
作者：
Sheybani,Roya;Cobo,Angelica;Meng,Ellis
我们提出了一个完全集成的植入式电解为基础的微型泵与纳入EI剂量传感器。无线供电和数据遥测（通过振幅和频率调制）被用来实现可变流量控制和与传感器的双向数据链路。无线输注速率控制（0.14-1.04 μL/min）和剂量感应（0.55-2 μL的推注分辨率）分别使用最终电路架构进行校准，然后演示了同时无线流量控制和剂量感应。研究了使用加药系统的膨胀检测，以及线圈间隔距离和未对准在无线功率和数据传输中的影响。设计了一个定制的常闭弹簧加载球形止回阀，并将其安装在储液器出口处，以防止由于电解气体重新组合引起的反向压力梯度而导致的流体回流。在模拟脑组织中实现了成功输送、输注速率控制和剂量感测。
We present a fully integrated implantable electrolysis-based micropump with incorporated EI dosing sensors. Wireless powering and data telemetry (through amplitude and frequency modulation) were utilized to achieve variable flow control and a bi-directional data link with the sensors. Wireless infusion rate control (0.14–1.04 μL/min) and dose sensing (bolus resolution of 0.55–2 μL) were each calibrated separately with the final circuit architecture and then simultaneous wireless flow control and dose sensing were demonstrated. Recombination detection using the dosing system, as well as, effects of coil separation distance and misalignment in wireless power and data transfer were studied. A custom-made normally closed spring-loaded ball check valve was designed and incorporated at the reservoir outlet to prevent backflow of fluids as a result of the reverse pressure gradient caused by recombination of electrolysis gases. Successful delivery, infusion rate control, and dose sensing were achieved in simulated brain tissue.