Family history assessment - Strategies for prevention of cardiovascular disease
Family history assessment - Strategies for prevention of cardiovascular disease
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DOI：
10.1016/s0749-3797(02)00586-x
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发表时间：
2003-02-01
影响因子：
5.5
通讯作者：
Adams, TD
中科院分区：
文献类型：
--
作者：
Hunt, SC;Gwinn, M;Adams, TD
家族史评估可用于将全人群的健康促进和降低风险努力与高风险、有针对性的方法相结合，以帮助减轻心血管疾病(CVD)的负担。家族史是心血管疾病的独立预测因子，家族史分布的上半部分解释了人群中心血管疾病的比例高于其他风险因素(如血压和胆固醇)的极值所能解释的比例。积极的家族疾病病史通过识别具有可测量和未测量的风险因素组合的家庭来捕捉基因-基因和基因-环境相互作用的潜在复杂性，这些风险因素导致疾病表现。家族史是确定最普遍的心血管疾病病例和全人口疾病预防努力的有用工具。阳性的家族史也确定了心血管疾病高危人群中相对较少的家庭，他们可能从有针对性的筛查和密集干预中受益最大。
Family history assessment can be used to combine population-wide health promotion and risk-reduction efforts with a high-risk, targeted approach to help reduce the burden of cardiovascular disease (CVD). Family history is an independent predictor of CVD, and the upper portion of the family history distribution explains a larger fraction of CVD in the population than can be explained by extreme values of other risk factors (e.g., blood pressure and cholesterol). A positive family history of disease captures the underlying complexities of gene-gene and gene-environment interactions by identifying families with combinations of risk factors, both measured and unmeasured, that lead to disease expression. Family history is a useful tool for identifying Most prevalent cases of CVD and for population-wide disease-prevention efforts. A positive family history also identifies the relatively small subset of families in the population at highest risk for CVD who may benefit most from targeted screening and intensive intervention.