A novel method of endoscopic mucosal resection using sodium hyaluronate
A novel method of endoscopic mucosal resection using sodium hyaluronate
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DOI：
10.1016/s0016-5107(99)70234-8
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发表时间：
1999-08-01
影响因子：
7.7
通讯作者：
Kanai, N
中科院分区：
文献类型：
--
作者：
Yamamoto, H;Yube, T;Kanai, N
背景：生理盐水辅助的内窥镜切除是一种公认的治疗方法。然而，在注射生理盐水后，有时很难保持理想的组织隆起水平。因此，我们决定使用一种粘性物质，如透明质酸钠来代替生理盐水。方法：用两只猪胃和五只狗作为研究对象。将粘膜下注射透明质酸钠所产生的隆起与生理盐水所产生的隆起进行比较。结果：与生理盐水注射相比，透明质酸钠粘膜下注射产生的粘膜隆起持续时间更长，边缘更清晰。结论：用透明质酸钠替代生理盐水行鼻内窥镜下黏膜切除术，可使手术更为简便、可靠。
Background: Saline-assisted endoscopic resection is an established therapeutic method. However, it is sometimes difficult to maintain a desired level of tissue elevation after injection of saline. Therefore we decided to use a mucinous substance such as sodium hyaluronate instead of saline.Methods: Two resected porcine stomachs and five dogs were used for the study. The elevations, made by submucosal injections of sodium hyaluronate, were compared with those produced with normal saline. Sodium hyaluronate-assisted mucosal resections were compared with the saline-assisted resections.Results: Mucosal elevations created by submucosal injections of sodium hyaluronate remained for a longer time with a clearer margin compared to those made by saline injection. Endoscopic mucosal resections were performed safely with the assistance of sodium hyaluronate.Conclusions: Use of sodium hyaluronate instead of saline for endoscopic mucosal resection could make the procedure easier and more reliable.