The onset of visual experience gates auditory cortex critical periods.
The onset of visual experience gates auditory cortex critical periods.
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DOI：
10.1038/ncomms10416
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发表时间：
2016-01-20
影响因子：
16.6
通讯作者：
Sanes DH
中科院分区：
文献类型：
--
作者：
Mowery TM;Kotak VC;Sanes DH
感觉系统在发育过程中相互影响，剥夺会导致跨模态可塑性。由于听觉功能在视觉之前开始，我们通过评估早期、正常和延迟眼睑开放对听力损失引起的膜和抑制性突触特性变化的影响，研究了听觉皮层关键期（CP）期间操纵视觉体验的效果。早期的眼睑开放会使听觉皮层CP过早闭合，而黑暗饲养会阻止这种效应。相比之下，延迟眼睑开放延长了几天额外的听觉皮层CP。用于听力损失恢复的CP也通过早期眼睑张开而过早闭合，并通过延迟眼睑张开而延长。此外，当再加上短暂的听力损失，动物通常完全恢复，非常早期的视觉经验导致抑制缺陷，持续到成年。最后，我们展示了从视觉到听觉皮层的功能投射，可以调解这些影响。 视觉和听觉系统在发育过程中相互影响。在这里，作者表明，眼睑张开的开始调节听觉皮层对听力损失或听力恢复敏感的临界点
Sensory systems influence one another during development and deprivation can lead to cross-modal plasticity. As auditory function begins before vision, we investigate the effect of manipulating visual experience during auditory cortex critical periods (CPs) by assessing the influence of early, normal and delayed eyelid opening on hearing loss-induced changes to membrane and inhibitory synaptic properties. Early eyelid opening closes the auditory cortex CPs precociously and dark rearing prevents this effect. In contrast, delayed eyelid opening extends the auditory cortex CPs by several additional days. The CP for recovery from hearing loss is also closed prematurely by early eyelid opening and extended by delayed eyelid opening. Furthermore, when coupled with transient hearing loss that animals normally fully recover from, very early visual experience leads to inhibitory deficits that persist into adulthood. Finally, we demonstrate a functional projection from the visual to auditory cortex that could mediate these effects. Visual and auditory systems influence each other during development. Here, the authors show that the onset of eyelid opening regulates critical points during which the auditory cortex is sensitive to hearing loss or the restoration of hearing