Evaluation of the relationship between macrophage migration inhibitory factor level and clinical course in patients with COVID-19 pneumonia
Evaluation of the relationship between macrophage migration inhibitory factor level and clinical course in patients with COVID-19 pneumonia
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DOI：
10.1002/jmv.27189
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发表时间：
2021-07-22
影响因子：
12.7
通讯作者：
Askin, Seda
中科院分区：
文献类型：
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作者：
Aksakal, Alperen;Kerget, Bugra;Askin, Seda
肆虐我们世界一年多的新冠肺炎疫情仍在影响我们的议程，其强度会随着时间的推移而波动。在我们的研究中，我们旨在确定不同预后的新冠肺炎患者血清迁移抑制因子水平与疾病严重程度的相关性。研究对象为2020年10月15日至2021年1月20日期间确诊为新冠肺炎的18岁以上患者和40名志愿医护人员。采用双抗体夹心酶联免疫吸附试验检测MIF水平。在对患者和对照组血清MIF值的比较中，发现新冠肺炎中、重度患者的MIF值均显著高于对照组(p=0.001，0.001)。比较中、重度新冠肺炎患者血清MIF值，发现重度患者血清MIF值较高(p=0.001)。受试者工作特征曲线分析用于区分重度和中度新冠肺炎患者的MIF水平，曲线下面积为0.78。以4.455 ng/ml为临界值，其敏感性为83%，特异性为62%。未能充分平衡新冠肺炎合成的促炎细胞因子与抗炎作用是导致病程加重的最重要原因。MIF在促炎细胞因子的合成中起着重要作用，可以为疾病的早期预后提供重要信息。
The COVID-19 pandemic, which has ravaged our world for more than a year, still shapes our agenda with a scale of intensity that fluctuates over time. In our study, we aimed to determine the correlation between serum migration inhibitory factor (MIF) level and disease severity in COVID-19 with different prognoses. Between 15 October 2020 and 20 January 2021, 110 patients over the age of 18 who were diagnosed with COVID-19 and 40 volunteer healthcare personnel were included in our study. MIF levels were measured by enzyme-linked immunosorbent assay. In the comparison of serum MIF values in the patient and control group, it was observed that the MIF level was significantly higher in patients with both moderate and severe COVID-19 levels compared to the control group (p = 0.001, 0.001). In the comparison of serum MIF values of moderate to severe COVID-19 patients, it was observed that MIF level was higher in severe patients (p = 0.001). In the receiver operating characteristic curve analysis performed to differentiate between severe and moderate COVID-19 patients with MIF levels, the area under the curve was observed as 0.78. When the cutoff value of the MIF level was taken as 4.455 ng/ml, the sensitivity was 83% and the specificity was 62%. Failure to adequately balance the pro-inflammatory cytokines synthesized in COVID-19 with anti-inflammatory effect is the most important reason for the aggravation of the disease course. Playing a role in pro-inflammatory cytokine synthesis, MIF can provide important information about the disease prognosis in the early period.