PRESSURE-DEPENDENT CHANGES IN CONFIGURATION OF ENDOTHELIAL TUBULES OF SCHLEMMS CANAL
PRESSURE-DEPENDENT CHANGES IN CONFIGURATION OF ENDOTHELIAL TUBULES OF SCHLEMMS CANAL
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DOI：
10.1016/s0002-9394(14)76301-9
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发表时间：
1974-01-01
影响因子：
4.2
通讯作者：
JOHNSTONE, MA
中科院分区：
文献类型：
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作者：
JOHNSTONE, MA
在1830年描述了施莱姆运河之后，显微镜学家开始寻找允许水通过小梁网进入该运河的通道。自1963年Grant2将注意力集中在开角型青光眼的小梁网异常血流区域以来，这项研究获得了更大的意义。尽管有深入的研究，水通过小梁内皮到施勒姆管的方式仍然不确定。1972年，Inomata、Bill和Smelser3用电子显微镜观察了猴子的眼睛。他们证明，一些红细胞和Thorotrast可以直接通过细胞内的孔或通道在小血管内皮。1972年，Bill和Svedbergh使用扫描电子显微镜在人眼中发现了类似的通道或毛孔。他们认为这些开口的大小和数量足以解释房水流入施勒姆管的原因。其他研究者没有发现通过内皮的直接通道。Shabo和Max well在1973年也用扫描电子显微镜检查了猴子的眼睛，用辣根过氧化物酶和红细胞作为示踪剂。他们发现血管内壁的内皮是一个完整的无孔膜，没有直接通过内皮到施莱姆管的通道。在同一项研究中，Shabo和Maxwell描述了由区域形成的绒毛结构
After the description of Schlemm's canal in 1830, 1 microscopists began to search for channels permitting aqueous passage through the trabecular meshwork to this canal. The search has attained added significance since Grant2 in 1963 focused attention on the trabecular meshwork as the area of abnor mal flow in open-angle glaucoma. Despite intensive study, the manner of aqueous pas sage through the trabecular endothelium to Schlemm's canal remains uncertain. In 1972, Inomata, Bill, and Smelser3 ex amined monkey eyes by electron microscopy. They demonstrated that some red blood cells and Thorotrast can pass directly through intracellular pores or channels in the tra becular endothelium. Bill and Svedbergh, 4 in 1972, found similar channels or pores in human eyes using scanning electron micro scopy. They believe the size and number of these openings are sufficient to account for the flow of aqueous humor into Schlemm's canal.Other investigators do not find direct channels through the endothelium. This is illustrated by the work of Shabo and Max well, 5 who in 1973 also examined monkey eyes by scanning electron microscopy using horseradish peroxidase and red blood cells as tracers. They found the endothelium lining the canal to be a complete nonfenestrated membrane with no channels directly through the endothelium to Schlemm's canal. In the same study Shabo and Maxwell described villus structures formed by regions