Homing of Cancer Cells to the Bone
Homing of Cancer Cells to the Bone
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DOI：
10.1007/s12307-011-0083-6
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发表时间：
2011-12-01
影响因子：
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通讯作者：
Taichman, Russell S.
中科院分区：
文献类型：
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作者：
Mishra, Anjali;Shiozawa, Yusuke;Taichman, Russell S.
多种肿瘤细胞优先生长在骨骼上。癌细胞归巢到骨骼是一个多步骤的过程，包括肿瘤的恶性进展，肿瘤通过细胞外基质和血管侵袭，以及肿瘤细胞在骨骼中的定居。对癌细胞在这些过程中使用的机制有了更深入的了解，将有助于设计专门针对归巢过程的药物。在这篇综述中，我们将讨论肿瘤细胞的特性和促进癌细胞归巢到骨的骨微环境。我们将重点介绍癌细胞转移到骨骼时所涉及的不同步骤和分子途径。由于骨是造血干细胞(HSCs)的主要来源，我们还将强调癌症归巢与HSC到骨的相似性。最后，我们将总结治疗和早期检测策略，这些策略可以防止癌细胞归巢到骨骼。
A variety of tumor cells preferentially home to the bone. The homing of cancer cells to the bone represents a multi-step process that involves malignant progression of the tumor, invasion of the tumor through the extracellular matrix and the blood vessels and settling of the tumor cells in the bone. Gaining a greater understanding as to the mechanisms used by cancer cells in these processes will facilitate the design of drugs which could specifically target the homing process. In this review we will discuss the properties of tumor cells and the bone microenvironment which promote homing of a cancer cell to the bone. We will highlight the different steps and the molecular pathways involved when a cancer cellmetastasize to the bone. Since bone is the major home for hematopoietic stem cells (HSCs), we will also highlight the similarities between the homing of cancer and HSC to the bone. Finally we will conclude with therapeutic and early detection strategies which can prevent homing of a cancer cell to the bone.