EXTRACELLULAR SEQUESTRATION AND RELEASE OF FIBROBLAST GROWTH-FACTOR - A REGULATORY MECHANISM
EXTRACELLULAR SEQUESTRATION AND RELEASE OF FIBROBLAST GROWTH-FACTOR - A REGULATORY MECHANISM
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DOI：
10.1016/0968-0004(91)90102-2
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发表时间：
1991-07-01
影响因子：
13.8
通讯作者：
FUKS, Z
中科院分区：
文献类型：
--
作者：
VLODAVSKY, I;BARSHAVIT, R;FUKS, Z
碱性成纤维细胞生长因子促进新的毛细血管的形成，并通过与细胞表面和细胞外基质中的硫酸肝素(HS)结合来隔离和保护。肝素类分子和HS降解酶(即肝素酶)释放HS结合的碱性成纤维细胞生长因子为调节正常和病理情况下的毛细血管生长提供了一种新的机制。细胞外基质也是其他生长因子和酶的储存库。
Basic fibroblast growth factor, (bFGF), promotes the formation of new blood capillaries and is sequestered and protected by binding to heparan sulfate (HS), both on the cell surface and in the extracellular matrix. Release of HS-bound bFGF by heparin-like molecules and HS-degrading enzymes (i.e., heparanase) provides a novel mechanism for regulation of the growth of capillary blood vessels in normal and pathological situations. The extra-cellular matrix also serves as a storage depot for other growth factors and enzymes.