Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system
Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system
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DOI：
10.1002/glia.10148
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发表时间：
2002-11-01
期刊：
影响因子：
6.2
通讯作者：
Silverstein, SC
中科院分区：
文献类型：
--
作者：
Husemann, J;Loike, JD;Silverstein, SC
A类清道夫受体（SR-A、CD 204）、清道夫受体-BI（SR-BI）和CD 36是细胞表面蛋白，介导细胞与各种天然和病理修饰物质的粘附和内吞，并参与细胞内信号传导、脂质代谢和宿主对细菌病原体的防御。小胶质细胞、Mato细胞、星形胶质细胞、脑微血管内皮细胞、脑动脉平滑肌细胞和视网膜色素上皮细胞表达这些SR中的一种或多种。新生小胶质细胞表达SR-A和SR-BI，而正常小鼠和成人脑中的小胶质细胞均不表达。成人脑中的星形胶质细胞表达SR-BI。在阿尔茨海默病中，SR-A的小胶质细胞表达增加。这些发现，以及SR-A和SR-BI分别介导小胶质细胞和星形胶质细胞对纤维状P-淀粉样蛋白的粘附和内吞，以及SR-A、SR-BI和CD 36参与小胶质细胞分泌活性氧的证据，表明这些受体在稳态和神经病理学中的作用。(C)2002 Wiley-Liss，Inc.
Scavenger receptor class A (SR-A, CD204), scavenger receptor-BI (SR-BI), and CD36 are cell surface proteins that mediate cell adhesion to, and endocytosis of, various native and pathologically modified substances, and participate in intracellular signaling, lipid metabolism, and host defense against bacterial pathogens. Microglia, Mato cells, astrocytes, cerebral microvascular endothelial cells, cerebral arterial smooth muscle cells, and retinal pigment epithelial cells express one or more of these SR. Expression of SR-A and SR-BI by microglia is developmentally regulated. Neonatal microglia express SR-A and SR-BI, while microglia in normal mouse and human adult brain express neither. Astrocytes in adult brain express SR-BI. In Alzheimer's disease, microglial expression of SR-A is increased. Such findings, and evidence that SR-A and SR-BI mediate adhesion and endocytosis of fibrillar P-amyloid by microglia and astrocytes, respectively, and that SR-A, SR-BI, and CD36 participate in secretion of reactive oxygen species by microglia, suggest roles for these receptors in homeostasis and neuropathology. (C) 2002 Wiley-Liss, Inc.