An ancient subcortical circuit decides when to orient to threat in humans
An ancient subcortical circuit decides when to orient to threat in humans
复制标题
古老的皮层下回路决定何时应对人类的威胁
DOI：
10.1101/2023.10.24.563636
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Trier H
中科院分区：
文献类型：
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作者：
Trier H
许多精神症状与威胁相关的感知和学习过程有关。然而，除此之外，也可能存在有效平衡威胁和奖励相关行为的机制，这些机制也可能因个体而异。我们用7T fMRI研究了与觅食奖励和警惕威胁之间自发切换相关的神经活动。在虚拟的自然环境中，参与者可以自由地在两种行为模式之间切换。转换是由对威胁和回报可能性的估计驱动的。跟踪威胁和切换到警惕与特定的，但分布的活动模式跨越缰核，中缝背核（DRN），前扣带皮层，前扣带皮层。不同的分布式模式预示着回报导向行为的回归。DRN活性的个体差异反映了警惕性的个体差异。所有的活动模式都被复制在最初保留的数据部分中。
Many psychiatric symptoms have been linked to threat-related perception and learning processes. In addition, however, there may also be mechanisms for balancing effectively between threat- and reward-related behaviors and these may also vary between individuals. We investigated neural activity associated with spontaneous switching between foraging for rewards and vigilance for threats with 7T fMRI. In a virtual naturalistic environment, participants freely switched between the two modes of behavior. Switching was driven by estimates of likelihood of threat and reward. Both tracking of threat and switching to vigilance were associated with specific but distributed patterns of activity spanning habenula, dorsal raphe nucleus (DRN), anterior cingulate cortex, and anterior insula cortex. Distinct distributed patterns heralded returns to reward-oriented behavior. Individual variation in DRN activity reflected individual variation in vigilance. All activity patterns were replicated in an initially held-out portion of data.