Host factors that contribute to recurrent staphylococcal skin infection.
Host factors that contribute to recurrent staphylococcal skin infection.
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导致复发性葡萄球菌皮肤感染的宿主因素。
DOI：
10.1097/qco.0000000000000156
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发表时间：
2015-06
影响因子：
3.9
通讯作者：
Daum RS
中科院分区：
文献类型：
--
作者：
Montgomery CP;David MZ;Daum RS
金黄色葡萄球菌是美国和其他地区皮肤和软组织感染 (SSTI) 的最常见原因。金黄色葡萄球菌 SSTI 患者经常发生反复感染，这强调需要更好地了解针对这些感染的保护性免疫的性质。在这里，我们回顾了有关金黄色葡萄球菌 SSTI 易感宿主因素的最新发现。近一半的金黄色葡萄球菌 SSTI 患者会出现复发性感染。流行病学和环境因素，例如接触医疗保健、年龄、与金黄色葡萄球菌 SSTI 的家庭接触以及受污染的家庭污染物，都与复发有关。大多数人都有抗葡萄球菌抗体的证据，但这些抗体是否具有保护作用仍然是个谜。相比之下，最近的临床和实验结果清楚地强调了先天免疫和 T 细胞介导的免疫在防御这些感染中的关键作用。金黄色葡萄球菌通过许多最近阐明的机制干扰先天性和适应性免疫。复发性金黄色葡萄球菌 SSTI 很常见，表明这些患者的保护性免疫力不完整或缺乏。我们对针对反复感染的保护性免疫的理解并不完整，迫切需要进一步的基础和转化研究来设计预防和治疗这些感染的策略。
Staphylococcus aureus is the most common cause of skin and soft tissue infections (SSTI) in the United States and elsewhere. Recurrent infections occur frequently in patients with S. aureus SSTI, underscoring the need to better understand the nature of protective immunity against these infections. Here, we review recent findings concerning the host factors that predispose to S. aureus SSTI. Recurrent infections occur in nearly half of all patients with S. aureus SSTI. Epidemiologic and environmental factors, such as exposure to health care, age, household contacts with S. aureus SSTI, and contaminated household fomites are associated with recurrence. The majority of the population has evidence of antistaphylococcal antibodies, but whether these are protective remains enigmatic. In contrast, recent clinical and experimental findings clearly highlight the critical roles of innate and T cell-mediated immunity in defense against these infections. S. aureus interferes with innate and adaptive immunity by a number of recently elucidated mechanisms. Recurrent S. aureus SSTIs are common, suggesting incomplete or absent protective immunity among these patients. Our understanding of protective immunity against recurrent infections is incomplete, and further basic and translational investigation is urgently needed to design strategies to prevent and treat these infections.