Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke - A study in baboon model
Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke - A study in baboon model
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DOI：
10.1161/atvbaha.107.158709
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发表时间：
2008-06-01
影响因子：
8.7
通讯作者：
Bouchama, Abderrezak
中科院分区：
文献类型：
--
作者：
Roberts, George T.;Ghebeh, Hazem;Bouchama, Abderrezak
目的-严重中暑是热浪期间发病和死亡的主要原因。中暑时组织损伤、器官衰竭和死亡的发病机制尚不清楚。方法和结果-我们研究了麻醉狒狒（狒狒）在受到环境热应激直至核心温度达到 42.5 摄氏度（中度中暑；n = 3）或以跌倒为标志的严重中暑（n = 4）发作时中暑引起的组织损伤和细胞死亡的途径。 收缩压至
Objective-Severe heatstroke is a leading cause of morbidity and mortality during heat waves. The pathogenesis of tissue injury, organ failure, and death in heatstroke is not well understood.Methods and Result-We investigated the pathways of heatstroke-induced tissue injury and cell death in anesthetized baboons (Papio hamadyras) subjected to environmental heat stress until core temperature attained 42.5 degrees C (moderate heatstroke; n = 3) or onset of severe heatstroke (n = 4) signaled by a fall in systolic blood pressure to