Structural revision of harrisonin and 12 beta-acetoxyharrisonin, two limonoids from Harrisonia abyssinica
Structural revision of harrisonin and 12 beta-acetoxyharrisonin, two limonoids from Harrisonia abyssinica
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DOI：
10.1021/np970201p
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发表时间：
1997-08-01
影响因子：
5.1
通讯作者：
Fischer, NH
中科院分区：
文献类型：
--
作者：
Rajab, MS;Rugutt, JK;Fischer, NH
用现代一维和二维核磁共振波谱方法对从海桑根皮中分离得到的柠檬苦素类化合物harrisonin（1）和12 β-乙酰氧基harrisonin（2）的结构进行了重新分析，并用单晶X-射线衍射法确定了12 β-乙酰氧基harrisonin的分子结构和相对构型。获得的光谱结果需要修改这些化合物的结构从1和2到3和4，分别。新的分子结构3和4显示了一个新的柠檬苦素骨架与一个独特的五元环B。
The structures of the known limonoids harrisonin (1) and 12 beta-acetoxyharrisonin (2), isolated from the root bark of Harrisonia abyssinica, were reanalyzed-by modern 1D and 2D NMR spectroscopic methods, and the molecular structure and relative configuration of 12 beta-acetoxyharrisonin were determined by single-crystal X-ray diffraction. The spectral findings obtained require revision of the structures of these compounds from 1 and 2 to 3 and 4, respectively. The new molecular structures 3 and 4 display a novel limonoid skeleton with a unique five-membered ring B.