Cholecystokinin-immunoreactive neurons in rat and monkey cerebral cortex make symmetric synapses and have intimate associations with blood vessels.
Cholecystokinin-immunoreactive neurons in rat and monkey cerebral cortex make symmetric synapses and have intimate associations with blood vessels.
复制标题
大鼠和猴子大脑皮层中的胆囊收缩素免疫反应性神经元形成对称突触，并与血管密切相关。
DOI：
10.1073/pnas.80.8.2400
复制
发表时间：
1983
影响因子：
11.1
通讯作者：
Beinfeld,MC
中科院分区：
文献类型：
--
作者：
Hendry,SH;Jones,EG;Beinfeld,MC
用免疫细胞化学光镜和电镜观察了大鼠和猴大脑皮质中胆囊收缩素样免疫反应神经元（CCK神经元）。CCK神经元主要是双极细胞，存在于大鼠大脑皮层的所有层和所有区域。CCK神经元在猴皮质的所有检查区域（中央前回和中央后回以及上级顶叶小叶）中也被发现。CCK神经元的胞体和树突接受的突触相对较少，但轴体和轴树突触均为对称和不对称的，大多数CCK阳性的轴突终末与锥体和非锥体神经元的胞体和近端树突形成对称性突触。CCK神经元的胞体和突起也被发现与血管和其他神经元建立非常密切的非突触联系，这表明该肽在维持神经元兴奋性和脑血流中可能起作用。
Neurons displaying cholecystokinin-like immunoreactivity (CCK neurons) in rat and monkey cerebral cortex were examined by light and electron microscopic immunocytochemistry. CCK neurons were found to be mainly bipolar cells present in all layers and in all areas of the rat cerebral cortex. CCK neurons were also found in all regions examined in monkey cortex (pre- and post-central gyri and superior parietal lobule). The somata and the dendritic processes of CCK neurons receive relatively few synapses but both symmetric and asymmetric axosomatic and axodendritic synapses were found. The majority of axon terminals displaying CCK-like immunoreactivity formed symmetric synapses, most frequently with the somata and proximal dendrites of pyramidal and nonpyramidal neurons. The somata and processes of CCK neurons were also found to establish very close nonsynaptic associations with blood vessels and with other neurons, suggesting possible roles for the peptide in the maintenance of neuronal excitability and cerebral blood flow.