The Effect of Octanoic Acid on Essential Voice Tremor: A Double-Blind, Placebo-Controlled Study.
The Effect of Octanoic Acid on Essential Voice Tremor: A Double-Blind, Placebo-Controlled Study.
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辛酸对原发性声音震颤的影响：一项双盲、安慰剂对照研究。
DOI：
10.1002/lary.27695
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Mihaila,Dragos
中科院分区：
文献类型：
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作者：
Lowell,SorenY;Kelley,RichardT;Monahan,Marika;Hosbach-Cannon,CarlyJo;Colton,RaymondH;Mihaila,Dragos
目的/假设本研究的目的是确定辛酸对特发性发声震颤 (EVT) 的声学、知觉和功能方面的影响。研究设计前瞻性、双盲、安慰剂对照、交叉研究。方法十六名被诊断为 EVT 的参与者被随机分配到辛酸或安慰剂的 3 周给药条件下，然后是 2 周的洗脱期，然后交叉到其他条件下进行为期 3 周的辛酸或安慰剂给药。额外3周。在每个条件完成之前和完成时完成基线和后测试课程。主要结果测量是根据声信号测量的振幅和频率震颤的幅度。次要结果是震颤严重程度的听觉感知评级和声音障碍的自我评级。结果与安慰剂条件相比，辛酸给药 3 周后震颤的幅度和频率显着降低。震颤严重程度的听觉感知评级在不同条件下没有显示出显着差异。持续元音评分呈现出更好声音的趋势，但句子级别评分却没有。根据语音障碍指数 10 评估，自我报告的语音障碍在不同情况下没有显着差异。结论这项对照调查的结果支持辛酸在降低 EVT 患者震颤程度方面的潜在效用。需要进一步研究以确定不同的剂量或治疗组合是否可以改善 EVT 的功能沟通。证据水平1Laryngoscopy, 129:1882–1890, 2019
Objectives/HypothesisThe purpose of this study was to determine the effects of octanoic acid on acoustic, perceptual, and functional aspects of essential voice tremor (EVT).Study DesignProspective, double‐blind, placebo‐controlled, crossover study.MethodsSixteen participants with a diagnosis of EVT were randomized to a 3‐week dosing condition of octanoic acid or placebo, followed by a 2‐week washout period and crossover to the other condition for an additional 3 weeks. Baseline and post‐testing sessions were completed before and at the completion of each condition. Primary outcome measures were the magnitude of amplitude and frequency tremor, measured from the acoustic signal. Secondary outcomes were auditory‐perceptual ratings of tremor severity and self‐ratings of voice handicap.ResultsMagnitude of amplitude and frequency tremor were significantly lower after 3 weeks of octanoic acid dosing as compared to the placebo condition. Auditory‐perceptual ratings of tremor severity did not show significant differences between conditions. A trend toward better voice was seen for the sustained vowel ratings, but not the sentence‐level ratings. No significant differences between conditions were seen on self‐reported voice disability as assessed on the Voice Handicap Index‐10.ConclusionsThe results of this controlled investigation support the potential utility of octanoic acid for reducing the magnitude of tremor in people with EVT. Further research is needed to determine whether different dosing or treatment combinations can improve functional communication in EVT.Level of Evidence1Laryngoscope, 129:1882–1890, 2019