Usefulness of Urinary N-Terminal Fragment of Titin to Predict Mortality in Dilated Cardiomyopathy
Usefulness of Urinary N-Terminal Fragment of Titin to Predict Mortality in Dilated Cardiomyopathy
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DOI：
10.1016/j.amjcard.2018.01.046
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发表时间：
2018-05-15
影响因子：
2.8
通讯作者：
Takeishi, Yasuchika
中科院分区：
文献类型：
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作者：
Yoshihisa, Akiomi;Kimishima, Yusuke;Takeishi, Yasuchika
肌联蛋白与心肌僵硬和肥大相关，其基因突变已在心肌病如扩张型心肌病（DC）中被鉴定。最近有报道，在受损的肌肉中，肌联蛋白的N-末端片段（Titin-N）被钙蛋白酶-3切割，尿Titin-N（U-TN）可能是肌节损伤的标志物。我们的目的是研究U-TN对DC预后的影响。我们测定了102例DC患者尿中Titin-N/肌酐比值（U-TN/Cr; pmol/mg/dl），并随访所有患者（平均1,167天）。根据尿总氮/肌酐（U-TN/Cr）分为3组：第1组（U-TN/Cr
Titin is associated with myocardial stiffness and hypertrophy, and mutations in its gene have been identified in cardiac myopathies such as dilated cardiomyopathy (DC). It has recently been reported that in damaged muscle, the N-terminal fragment of titin (Titin-N) is cleaved by calpain-3, and urinary Titin-N (U-TN) could be a marker of sarcomere damage. We aimed to investigate the impact of U-TN on prognosis of DC. We measured urinary levels of Titin-N/creatinine ratio (U-TN/Cr; pmol/mg/dl) in 102 patients with DC, and followed up all the patients (mean 1,167 days). The patients were divided into 3 groups based on the U-TN/Cr: first (U-TN/Cr